Archives of Pharmacal Research

  • 제24권6호
  • /
  • Pages.613-617
  • /
  • 2001
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

NMDA-type Glutamatergic Modulation in Dopaminergic Activation Measured by Apomorphine-Induced Cage Climbing Behaviors

  • Jang, Choon-Gon (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University) ;
  • Lee, Seok-Yong (Department of Pharmacology, College of Pharmacy, Sungkyunkwan University)
  • 발행 : 2001.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The present study examined the hypothesis that NMDA, AMPA/Kainate, and metabotropic (mGlu) glutamate receptors contribute to a behavioral stimulation induced by activation of dopamine receptors by comparing responses in apomorphine-induced cage climbing behaviors in mice. MK-801, CNQX, and MCPG were served as the NMDA receptor, AMPA/Kainate receptor, and mGlu receptor antagonist, respectively, to elucidate the glutamatergic modulation in apomorphine-induced eopaminergic activation in mice. Drugs were administered intracerebroventricularly (i.c.v.) into the mouse brain 15 min before the apomorphine treatment (2 mg/kg, s.c.). 1.c.v. injection of MK-801 inhibited the apomorphine-induced cage climbing behavior dose-dependently. However, treatments with CNQX and MCPG did not any significant change in apomorphine-induced cage climbing behavior in mice. These results suggest that stimulation of NMDA type of glutamate receptors could contribute to the dopaminergic sti mutation, but not AMPA/Kainate and mGlu type glutamate receptors.

키워드

참고문헌

  1. Eur. J. Pharmacol. v.369 Group I mGlu receptor modulation of dopamine release in the rat striatum in vivo Bruton,R.K.;Ge,J.;Barnes,N.M.
  2. Neuroscience v.19 In vivo presynaptic controle of dopaine release in the cat caudate ecleus-II. Facilitatory or inhibitory influence of L-glutamate Cheramy,A.;Romo,R.;Godeheu,G.;Baruch,P.;Glowinski,J.
  3. Nature v.257 Rapid and dissociated changes in sensitivities of different dopamine receptors in mouse brain Costentin,J.;Protais,P.;Schwartz,J.C.
  4. J. Neurochem. v.42 Glutamate: a neurotransmitter in mammalian brain Fonnum,F.
  5. Br. J. Pharmacol. v.12 Pharmacological effects produced by intracerbral injection of drugs in the conscious mouse Haley,T.J.;McCormick,W.G.
  6. J. Neurochem. v.38 Effect of motor and premotor cortex ablation on concentrations of amino acids, monoamines, and acetyl-choline and on the ultrastructure in rat striatum. A confirmation of glutamate as the specific cortico-striatal transmitter Hassler, R. Hang;P.C.Nitsch;J.S.Kim;K.Paik
  7. Neuropharmacology v.26 Inhibition by phencyclidine of excitatory amino acid stimulated release of neurotransmitter in the nucleus accumbens Jones,S.M.;Snell,L.D.;Johnson,K.M.
  8. Life Sci. v.45 Blockade of "reverse tolerance" to cocaine and amphetamine by MK-801 Karler,R.;Calder,S.D.;Chaudhry,I.A.;Turkanis,S.A.
  9. Brain v.93 The corticostriate projection in the monkey Kemp,J.M.;Powell,T.P.S.
  10. Life Sci. v.58 Inhibition by noncompetitive NMDA receptor antagonists of apomorphine-induced climbing behavior in mice Kim,H.S.;Rhee,G.S.;Jung,J.Y.;Lee,J.H.;Jang,C.G.;Park,W.K.
  11. Brain Res. v.617 Effects of the AMPA/kainate receptor antagonist DNQX in the nucleus accumbens on drug-induced conditioned place preference Layer,R.T.;Uretski,N.J.;Wallace,L.J.
  12. Can. J. Physiol. Pharmacol. v.61 Regional release of [³H] dopamine from rat brain in vitro : Effects of opioids on release induced by potassium, nictine and L-glutamic acid Mariien,M.;Brien,J.;Jhamandas,K.
  13. Brain. Res. Rev. v.15 Physical and pathophysiological roles of excitatory amino acids during central nervous system development McDonald,J.W.;Johnston,M.V.
  14. Brain Res. v.128 A glutamatergic corticostriatal pathway? McGeer,P.L.;McGeer,E.G.;Scherer,U.;Singh,K.
  15. J. Neurochem. v.55 Stimulation of dopamine release from cultured rat mesencephalic cells by naturally occurring excitatory amino acids: involvemet of both N-methyl-D-aspartate (NMDA) and non-NMDA receptor subtypes Mount,H.;Quirion,R.;Chaudieu,I.;Boksa,P.
  16. Life Sci. v.53 L-NAME and MK-801 attenuate sensitization to the locomotor- stimulating effect of cocaine Pudiak,C.M.;Bozarth,M.A.
  17. Pharmacol. Biochem. Behav. v.40 Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin, or accumbens dopamine, but not caffeine Pulvirenti,L.S.;Swerdlow,N.R.;Koob,G.F.
  18. Neurosci. Lett. v.145 Endogenous extracellular glutamate accumulation in rat neocortical cultures by reversal of the transmembrane sodium gradient Taylor,C.P.;Geer,J.J.;Burke,S.P.
  19. Science v.251 Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801 Trujillo,A.K.;Akill,H.
  20. Psychopharmacology v.136 Effects of AMPA receptor antagonists on dopamine-mediated behaviors in mice Vanover,K.E.
  21. Neuroscience v.4 The effects of surgical and chemical lesions on neurotransmitter candidates on the nucleus accumbens Walaas,I.;Fonnum,F.
  22. J. Anat. v.99 The corticostriatal projection in the cat Webster,K.E.
  23. J. Pharmacol. Exp. Ther. v.260 α-Amino-3-hydroxy-5-methylisoxasole-4-proprionate/kainite receptor antagonists in the nucleus accumbens and ventral pallidum decrease the hypermotility response to psychomotor stimulant drugs Willins,D.L.;Wallace,L.J.;Miller,D.D.;Uretsky,N.J.
  24. J. Neurochem. v.47 Excitatory amino acid neurotransmitters in the corticostriatal pathway: Studies using intracerebral microdialysis in vivo Young,A.M.J.;Bradford,H.F.