Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Induction of Oral Tolerance to Japanese Cedar Pollen

  • Kim, Joung-Hoon (Department of herbal Resources, Professional Graduate School of Oriental medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Department of herbal Resources, Professional Graduate School of Oriental medicine, Wonkwang University) ;
  • Ahn, Seong-Hun (Department of herbal Resources, Professional Graduate School of Oriental medicine, Wonkwang University) ;
  • Park, Joung-Suk (Department of Pharmacy, Graduate School of Wonkwang University) ;
  • Woo, Won-Hong (Department of herbal Resources, Professional Graduate School of Oriental medicine, Wonkwang University)
  • Published : 2001.12.01
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Abstract

Oral tolerance is thought to play a role in preventing allergic responses and immune-mediated diseases. An improved mouse model of the oral tolerance to Japanese cedar pollen (JCP) as antigen was developed in order to detect induction of the tolerance, and the immunological characteristics of this model were also elucidated. Oral tolerance was induced by C3H/ HeN mice given an oral administration of 10 mg JCP 7 days before immunization with an i.p. injection of 0.1 mg JCP in complete Freunds adjuvant (CFA). The effects of oral JCP on systemic immunity were assessed by enzyme-linked immunosorbent assay (ELISA) of immunoglobulin (Ig) levels in serum collected on day 7 or 14 after immunization. Oral tolerance to JCP was adequately induced on day 7 after immunization and was more effective in C3H/HeN mice than in BALB/c mice. The tolerance was primarily concerned with the decreased serum levels of antigen-specific IgG. In these mice, oral administration of JCP also suppressed various immune responses to the antigen including delayed-type hypersensitivity (DTH), total Igl level and anti-JCP IgGl level. The suppression of these immune responses by the oral antigen was associated with a significant reduction in interleukin-4 (IL-4) production. These findings therefore indicate that this C3H/HeN mice model has potential use in detecting the induction of oral tolerance by JCP and suggest that this tolerance model may be effective in the treatment and prevention of allergic responses caused by the antigen.

Keywords

References

  1. J. Exp. Med. v.167 Heterogeneity of helper/inducer T lymphocytes. Ⅱ. Effects of interleukin-4- and interleukin-2-producing T cell clones on resting B lymphocytes Boom,W.H.;Liano,D.;Abbas,A.K.
  2. J. Exp. Med. v.177 In vivo role of interleukin-4 in T cell tolerance induced by aqueous protein antigen Burnstein,H.J.M.;Abbas,A.K.
  3. J. Exp. Med. v.152 Systemic tolerance and secretory immunity after oral immunization Challacombe,S.J.;Tomasi,T.B.
  4. Curr. Opin. Immunol. v.5 Immunotherapy of autoimmune disease Cooke,A.;Wraith,D.C.
  5. Eur. J. Immunol. v.18 Reversal by interferon-gamma of inhibition of delayed-type hypersensitivity induction by anti-CD4 or anti-interleukin-2 receptor (CD25) monoclonal antibodies. Evidence for the physiological role of the $CD4^+\;Th1^+$ subset in mice Diamantstein,T.;Eckert,R.;Volk,H.D.;Kupier-Weglinski,J.W.
  6. J. Immunol. v.109 Enzyme-linked immunosorbent assay. Ⅲ. Quantitation of specific antibodies of enzyme labeled anti-immunoglobulin in antigen-coated tubes Engvall,E.;Perlmann,P.
  7. Eur. J. Immunol. v.24 Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice Fishman-Lobell,J.;Friedman,A.;Weiner,H.L.
  8. J. Immunol. v.143 The role of interferon-gamma in delayed-type hypersensitivity mediated by Th1 clones Fong, T.A.;Mosmann,T.R.
  9. Proc. Natl. Acad. Sci. USA. v.91 Induction of energy or active suppression following oral tolerance is determined by antigen dosage Friedman,A.;Weiner,H.L.
  10. J. Immunol. v.154 T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction Garside,P.;Steel,M.;Worthey,E.A.;Satoskar,A.;Alexander,J.;Bluethmann,H.;Liew,F.Y.;Mowat,A.M.
  11. J. Immunol. v.145 Defective oral tolerance promotes nephritogenesis in experimental lgA nephropathy induced by oral immunization Gesualdo,L.;Lamm,M.E.;Emancipator,S.N.
  12. J. Immunol. v.128 Inhibition of specific immune responses by feeding protein antigens. Ⅲ. Induction of the tolerant state in the absence specific suppressor T cells Hanson,D.G.;Miller,S.D.
  13. J. Immunol. v.140 Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments Higgins,P.;Weiner,H.L.
  14. Clin. Exp. Allergy v.26 Detection of allergen-specific lgE in tears of grass pollen-allergic patients with allergic rhinoconjunctivitis Hoffmann-Sommergruber,K.;Ferreira,E.D.;Ebner,C.;Barisani,T.;Korninger,L.;Kraft,D.;Scheiner,O.;Baumgartner,I.
  15. J. Exp. Med. v.155 T cell-derived B cell differentiation factor(s): effect on the isotype switch of murine B cells Isakson,P.C.;Pure,E.;Vitetta,S.;Krammer,P.H.
  16. Int. Arch. Allergy Appl. Immunol. v.87 Comparison of guinea pig lgE antibodies estimated by ELISA with those estimated by passive cutaneous anaphylaxis Ito,K.;Ishii,A.;Yamashita,N.;Miyamoto,T.;Watanabe,N.
  17. J. Toxicol. Sci. v.20 Effects of diphenyl dimethyl dicarboxylate on oral tolerance to ovalbumin in mice Kim,J.H.;Ahn,Y.K.
  18. Biol. Pharm. Bull. v.18 Oral tolerance to ovalbumin in mice as a model for detecting modulators of the immunologic tolerance to a specific antigen Kim,J.H.;Ohsawa,M.
  19. Immunol. Res. v.7 Contrasuppression in the mucosal immune system Kiyono,H.;Green,D.R.;McGhee,J.R.
  20. J. Immunol. v.121 Immunological suppression after oral administration of antigen. 1. Specific suppressor cells formed in rat Peyers patches after oral administration of sheep erythrocytes and their systemic migration Mattingly,J.A.;Waksman,B.H.
  21. Eur. J. Immunol. v.23 Direct evidence for energy in T-lymphocytes tolerized by oral administration of ovalbumin Melamed,D.;Friedman,A.
  22. Int. Immunol. v.8 Peripheral tolerance of Th2 lymphocytes induced by continuous feeding of ovalbumin Melamed,D.;Fishman-Lobell,J.;Uni,Z.;Weiner,H.L.;Friedman,A.
  23. J. Immunol. v.128 Lipopolysaccharide (LPS) regulation of the immune response: LPS influence on oral tolerance induction Michalek,S.M.;Kiyono,H.;Wannemuehler,M.J.;Mosteller,L.M.;McGhee,J.R.
  24. J. Immunol. v.123 Inhibition of specific immune responses by feeding proteins. Ⅳ. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin Miller,S.D.;Hanson,D.G.
  25. Annu. Rev. Immunol. v.7 Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties Mosmann,T.R.;Coffman,R.L.
  26. Handbook of Mucosal Immunology Oral tolerance and regulation of immunity to dietary antigens Mowat,A.M.;Ogra,P.L.(ed.);Mestecky,J.(ed.);Lann,M.E.(ed.);Strober,W.(ed.);McGhee,J.R.(ed.);Bienesstock,J.(ed.)
  27. Immunol. Today v.8 The regulation of immune responses to dietary protein antigens Mowat,A.M.
  28. Immunology v.83 Regulation of DTH and lgE responses by IL-4 and IFN-γ in immunized mice givenpertussis toxin Mu,H.H.;Sewell,W.A.
  29. Immunology v.120 Suppressor T cells for lgE and lgG in Peyers patches of mice made tolerant by the oral administration of ovalbumin Ngan,J.;Kind,L.S.
  30. J. Immunol. v.144 Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen Nussenblatt,R.B.;Caspi,R.R.;Mahdi,R.;Chan,C.;Roberge,F.;Lider,O.;weiner,H.L.
  31. Cell v.57 Pleiotropy and redundancy: T cell derived lymphokine in the immune response Paul,W.E.
  32. J. Immunol. v.143 Evidence for differential induction of helper T cell subset during Trichinella spiralis infection Pond,L.;Wasson,D.L.;Hayes,C.
  33. Science v.236 Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate immuno-globulin isotype production Snapper,C.M.;Paul,W.E.
  34. Am. J. Respir. Crit. Care. Med. v.156 Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice Takano,H.;Yoshikawa,T.;Ichinose,T.;Miyabara,Y.;Imaoka,K.;Sagai,M.
  35. Annu. Rev. Immunol. v.12 Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens Weiner,H.L.;Friedman,A.;Miller,A.;Khoury,S.J.;Al-Sabbagh,A.;Santos,L.;Sayegh,M.;Nussenblatt,R.B.;Trentham,D.E.;Hafler,D.A.
  36. Inflamm. Res. v.48 An experimental allergic conjunctivitis induced by topical and repetitive applications of Japanese cedar pollens in guinea pigs Yasuda,M.;Kato,M.;Nakata,K.;Kohno,S.