Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-lipid Peroxidative Principles from the Stem Bark of Kalopanax pictus Nakai

  • Published : 2001.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Hepatic lipid peroxide contents were examined in bromobenzene-treated rats firstly after the oral administration of MeOH extract of Kalopanax pictus stem bark its n-BuOH fraction, EtOAc fraction and an alkaline hydrolysate of the n-BuOH fraction, and secondly after the intraperitoneal administration of hederagenin monodesmosides and bisdesmosides. Two hederagenin monodesmosides, kalopanaxsaponin A (KPS-A) and sapindoside C, exhibited significant anti-lipid peroxidation effects after intraperitoneal administration at doses of $10-30{\;}{\mu}mole/kg$, whereas their bisdesmosides did not exhibit any significant activity. These results suggest that it is the hederagenin monodesmosides that are responsible for anti-lipid peroxidation in vivo. The activity of KPS-A was established by the observation of decreased aminopyrine N-demethylase activity and increased epoxide hydrolase activity.

Keywords

References

  1. Biochem. Pharmacol. v.31 Multiple drug metabolism: P-nitroanisole reversal of acetone enhanced aniline hydroxylation Bidlack,W.R.;Lowery,G.L.
  2. J. Biol. Chem. v.249 Glutathione S-transferase: The first enzymatic step in mercapturic acid formation Habig,W.H.;Pabist,M.J.;Jakoby,W.B.
  3. Toxicology v.104 Effect of several metallothiionein inducers on oxidative stress defense mechanisms in rats Iszard,M.B.;Liu,J.;Klaassen,C.D.
  4. Biochem. Mol. Biol. Int. v.45 The prevention of carbon tetrachloride-induced hepatotoxicity in mice by α-hederin: inhibition of cytochorome P450 2E1 expression Jeong,H.C.;Park,H.Y.
  5. Biol. Pharm. Bull. v.21 Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites Kim,D.H.;Yu,K.W.;Bae,E.A.;Park,H.J.;Choi,J.W.
  6. Korean Resources Plants Kim,T.J.
  7. Arch. Pharm. Res. v.14 Triterpenoidal saponins from the leaves of Kalopanax pictum var. chinense Lee,M.;Hahn,D.R.
  8. Planta Medica v.66 Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosieds and bisdemosides isolated from the stem bark of Kalopanax pictus Lee,K.T.;Sohn,I.C.;Park,H.J.;Kim,D.W.;Park,K.Y.
  9. Anal. Biochem. v.95 Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction Ohkawa,H.;Ohishi,N.;Yagi,K.
  10. Arch. Pharm. Res. v.21 A potent anti-diabetic agent from Kalopanax pitus Park,H.J.;Kim,D.H.;Choi,J.W.;Park,J.H.;Han,Y.N.
  11. Planta Medica v.62 Protective effect of Oenanthe javanica on the hepatic lipid peroxidation in bromobenzene-treated rats and its bioactive component Park,J.C.;Yu,Y.B.;Lee,J.H.;Hattori,M.;Lee,C.J.;Choi,J.W.
  12. Planta Medica v.58 Cytotoxic activity of some triterpenoid saponins Quetin-Leclercq,J.;Elias,R.;Balansard,G.;Bassleer,R.;Angenot,L.
  13. Chem. Pharm. Bull. v.41 Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem.(Araliaceae) with synthesized bisdesmosides of oleanoic actid and hederagenin on carbon tetrachloride-induced hapatic injury Saito,S.;Ebashi,J.;Sumita,S.;Furumoto,T.;Nagamura,Y.;Nishida,K.;Isiguro,I.
  14. Chem. Pharm. Bull. v.39 Studies on the constituents of the the stem bark of Kalopanax pictus Sano,K.;Sanada,S.;Ida,Y.;Shoji,J.
  15. Chem. Pharm. Bull. v.37 Saponins from roots of Kalopanax septemlobus (Thunb.) Koidz, Ciqiu: Structures of kalopananx-saponins C,D,E and F Shao,C.J.;Kasai,R.;Xu,J.D.;Tanaka,O.
  16. Chem. Pharm. Bull. v.37 Saponins from leaves of Kalopanax septemlobus (Thunb.) Koidz: Structures of kalopananxsaponins La, Lb and Lc Shao,C.J.;Kasai,R.;Xu,J.D.;Tanaka,O.
  17. Chung Kuo Yao Hsueh Pao v.17 Effect of α-hederin and sapindoside B on hepatic microsomal cytochrome P-450 in mice Shi,J.Z.;Liu,G.T.