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The Pharmaceutical Society of Korea (대한약학회)
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Constituents of the Essential Oil of the Cinnamomum cassia Stem Bark and the Biological Properties

  • Published : 2001.10.01
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Abstract

CC-MS analysis on the essential oil (CC-oil) of Cinnamomum cassia stem bark led to the identification of cinnamaldehyde (CNA, 1), 2-hydroxycinnamaldehyde (2-CNA), coumarin (2), and cinnamyl acetate. The major volatile flavor in CC-oil was found to be 2-CNA. Coumarin was first isolated from this plant by photochemical isolation and spectroscopic analysis. CNA and CC-oil showed potent cytotoxicity, which was effectively prevented by N-acetyl-L-cysteine (NAC) treatment. Intraperitoneal administration with CNA considerably decreased malondialdehyde (MDA) formation and glutathione S-transferase activity in rats. These results suggest that CC-oil and CNA can regulate the triggering of hepatic drugmetabolizing enzymes by the formation of a glutathione-conjugate.

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References

  1. Biosciecnce and Biotechnological Biochemistry v.64 no.5 Inhibition of fungal cell wall synthesizing enzymes by trans-cinnamaldehyde Bang,K.H.;Lee,D.W.;Park,H.M.;Rhee,Y.H.
  2. Biochem. Pharmacology v.31 Multiple drug metabolism:P-nitroanisole reversal of acetone enhanced aniline hydroxylation Bidlack,W.R.;Lowery,G.L.
  3. J. Immuno. Methods. v.89 Rapid colorimetric assay for cell growth and survival:modification to the tetrazolium dye procedure giving improved sensitivity and reliability Denizot,F.;Lang,R.J.
  4. Mutagenesis v.13 no.1 The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides Dillon,D.;Combes,R.;Zeiger,E.
  5. J. Biol. Chem. v.249 Glutathione S-transferase : The first enzymatic step in mercapturic acid formation Habig,W.H.;Pabist,M.J.;Jakoby,W.B.
  6. Arch. Pharm. Res. v.21 no.2 Synthesis and in vitro cytotoxicity of cinnamaldehyde to human solid tumor cells Kwon,B.M.;Lee,S.H.;Choi,S.U.;Park,S.H.;Lee,C.O.;Cho,Y.K.;Sung,N.D.;Bok,S.H.
  7. Planta Medica v.65 Inhibition of human tumor growth by 2'-hydroxy-and 2'-benzoyloxycinnamaldehyde Lee,C.W;Hong,D.H.;Han,S.B.;Park,S.Y.;Kim,H.K.;Kwon,B.M.
  8. J. Biol. Chem. v.55 The colorimetric estimation of formaldehyde by means of the hantzsch reaction Nash,T.
  9. Anal. Biochem. v.95 Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction Ohkawa,H.;Ohishi,N.;Yagi,K.
  10. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase: Conversion in vitro of the enzyme activity from dehydrogenase(Type D)to oxidase(Type O) Stirpe,F.;Della,C.E.
  11. J. Biol. Chem. v.243 Studies of aldehyde oxidase by electron paramagnetic resonance spectroscopy Rajagopalan,K.V.;Fridovich,I.;Handler,P.;Palmer,G.;Beinert,H.
  12. Chinese Drugs of Plant Origin Tang,W.;Eisenbrand,G.