Archives of Pharmacal Research

  • 제24권4호
  • /
  • Pages.360-366
  • /
  • 2001
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Differential Distribution of Ganglioside GM3 in Seminiferous Tubule and Epididymis of Adult Rats

  • Jung, Kyu-Yong (Department of Pharmacology, Wonkwang University School of Medicine) ;
  • Kim, Bo-Hyun (Division of Biological Science, College of Natural Science, and Medicinal Research Center of Wonkwang University) ;
  • Cho, Mi-Ran (Division of Biological Science, College of Natural Science, and Medicinal Research Center of Wonkwang University) ;
  • Kim, Hyoung-Min (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Lee, Young-Choon (Department of Biotechnology, Dong-A University) ;
  • Kim, Cheorl-Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University) ;
  • Kim, Jin-Kyeoung (College of Medicine, Pochon CHA University, Infertility of Medical Centeral Hospital) ;
  • Kim, Byung-Jin (Department of Pharmacology, Wonkwang University School of Medicine) ;
  • Choo, Young-Kug (Department of Pharmacology, Wonkwang University School of Medicine)
  • 발행 : 2001.08.01
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초록

Gangliosides are ubiquitous membrane components in mammalian cells and are suggested to play important roles in various functions such as cell-cell interaction, adhesion, cell differentiation, growth control and signaling. Among all ganglio-series gangliosides, GM3 has the simplest carbohydrate structure, and has been shown as a major gangliosides, in male reproductive system. To study GM3 distribution in the seminiferous tubule and epididymis, frozen sections were stained with specific monoclonal antibody (MAb) against ganglioside GM3. In the seminiferous tubule of testis, pachytene spermatocytes and spermmatids expressed ganglioside GM3, but not in spermatogonia and sertoli cells. Spermatogonia and sertoli cells near the basement membrane were negatively reacted to anti-GM3. In the epididymis, GM3 was expressed only in some interstitial cells. Taken togethers, these results suggest that the expression of ganglioside GM3 in rat seminiferous tubule and epididymis is spatio-temporally regu lated during spermatogenesis.

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참고문헌

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