Archives of Pharmacal Research

  • 제24권3호
  • /
  • Pages.171-179
  • /
  • 2001
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Synthesis and Evaluation of the Analgesic and Antiinflammatory Activities of O-Substituted Salicylamides

  • Fahmy, H.H. (Department of Therapeutical Chemistry) ;
  • El-Eraky, W. (Department of Pharmacology, National Research Centre)
  • 발행 : 2001.06.01
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초록

The present investigation deals with the synthesis of some new salicylamidoacetyl sulfonamides 3a,b, salicylamido ethylacetate 4, salicylamido acetic acid hydrazide 5, which is considered as the key intermediate for the synthesis of several series of new compounds such as salicylamido pyrazol 6 and pyrazolone 1. N-imido-derivatives 9, 10, 11, thiadiazole 13, oxadiazole 14, 15, Schiffs bases 16a-f. Cyclocondensation of Schiffs bases with thioglycolic acid gave thiazolidinone 18a-c while with acetylchloride afforded azitidinones 19a-c and with acetic anhydride gave 1,4-benzoxazepine-3,5-dione. Some of the compounds were tested for their analgesic and antiinflammatory activities as well as ulcerogenic effects. Some derivatives were more effective than salicylamide and ulcerogenic activity was variably lowered .

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참고문헌

  1. Egypt. J. Pharm. Sci. v.35 Synthesis of Some 1,3,4-Oxadiazolines and Thiazolidinones of Expected Antibacterial Activity Abbas,S.E.;El-Ansary,S.L.;Mikhael,A.N.
  2. Egypt. J. Pharm. Sci. v.36 Synthesis and Reaction of Some Derivatives of Pyridazinylthioglycolic Acid Hydrazide with Possible Antimicrobial Activity Abdel-Motti,F.M.;Alafaleg,E.I.;Almehbad,N.Y.F.
  3. Arch. Intern. Pharamacodyn. v.134 Pharmacology of an Anti-tussive-1-Phenyl-2-propynyl-4-propinoxypiperidine acid Fumarate Charlier,R.;M.Prost;F.Binon;G.Deltour
  4. Martindale the Extrapharmacopoei(Thirtieth Edition) Coleman,D.L.;Wood,N.L.;Darling,W.M.;James,E.E.Reynolds(ed.)
  5. Acta Pharmacol., er. Toxicol. v.45 A New Anti-inflammatory Derivative of Indiazole Which Is Less Ulcerogenic than Indomethacin in Rats Corell,T.;Moller,J.K.;Splawinskim,J.
  6. IL. Farmaco v.44 no.5 Synthesis and Evaluation of the Analgesic and Antiinflammatory Activities of N-Substituted Salicylamides Daidone,G.;Raffa,D.;Piescia,S.
  7. Pharmazie v.29 no.9 Synthesis of Some New Semisynthetic Penicillins El-sebai,A.I.;Rida,S.M.;Beltagy,Y.A.;Abdel-Khalek,M.M.
  8. Egypt. J. Pharm. Sci. v.38 Synthesis of Some New Quinoline Derivatives of Potential Antimicrobial Activity Fahmy,H.H.
  9. Bull. Fac. Pharm. Cairo Univ. v.33 Synthesis of some new pyrazolones as potent antiinflammatory agent Fahmy,H.H.;W.Abdou,A.M.;El-eraky,W.
  10. Proceedings of the First International Scientific Conference (Science & Development), Fac. of Science Al-Azhar University Synthesis of Some New Oxadiazoles and Thiazoles of Quinoline Derivatives as Antimicrobial Agents Fathalla,O.A.;E.Kassem;M.M.Farouk,A.
  11. Vogels Text Book of Practical Organic Chemistry Furniss,B.S.;Hannaford,A.N.;Smith,P.W.G.;Tachel,A.R.;Longmann, Singapore Publishers(ed.)
  12. Proceedings of the First International Scientific Conference (Science & Development), Fac. of Science Al-Azhar University Synthesis of Some New Benzothiazole-2-Acrylic Acid Hydrazide Derivatives of Possible Biological Activity Kassem,E.M.M.;El-Masry,A.
  13. Egypt. J. Bilh. v.15 Synthesis of Some New Thiazolidinone Amide and Pyrazolidinones of Possible Inhibitory Effect on Biomphalaria Alexandrina Snail Enzymatic Activities Kassem,E.M.M.;El-difrawy,S.;Fathalla,O.A.;El-Ansary,A.;Abdou,W.A.M.
  14. J. Indian Chem. Soc. v.LXV Nizamuddin, Synthesis of Some 1-[5'-(Substituted-Phenoxymethyl)-1',3',4'-Thiadiazol-2'-yl]-4-Substituted-2-azetidinones as Potential Fungicides Kumar,R.;Giri,S.
  15. Statistical Methods Snedecol,W.G.;Cochran,G.W.
  16. J. Path. v.111 Distribution of Prostaglandin in Inflammatory Exudate Velo,G.P.;Dunn,C.T.;Giroud,J.P.;Timisit,J.;Willoughby,D.A.
  17. Proc. Soc. Exp. Biol. Med. v.111 Carrageenan Induced Oedema in Hind Paw of the Rat as an Assay for Antiinflammatory Drug Winter,C.A.;Risley,E.A.;Nuss,G.W.