YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Renal Action of Raclopride, a Dopamine $D_2$ Receptor Antagonist, in Dogs

Dopamine $D_2$ Receptor 차단제인 Raclopride의 신장작용

  • Published : 2001.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was attempted to investigate the effect of raclopride, a dopamine $D_2$ receptor antagonist, on renal function in dog. Raclopride (70-220$\mu\textrm{g}$/kg), when given intravenously, Produced antidiuresis along with the decrease in free water clearance ( $C_{H_2O}$), urinary excretion of sodium and potassium ( $E_{Na}$ , $E_{K}$), partially decreased osmolar clearance ( $C_{osm}$) and increased reabsorption rates of sodium and potassium in renal tubules ( $R_{Na}$ , $R_{K}$). Raclopride administered into a renal artery did not influence on renal function in small doses (10 and 30$\mu\textrm{g}$/kg), whereas exhibited the decrease of urine volume (Vol) and $C_{H_2O}$ both in experimental and control kidney in much dose (100$\mu\textrm{g}$/kg), at this time, the decreased rates of both Vol. and $C_{H_2O}$) were more prominent in control kidney rather than that elicited in experimental kidney, and then only via was decreased in control kidney but increased in experimental kidney. Raclopride administered via carotid artery (30-200$\mu\textrm{g}$/kg) did not influence at all on renal function. Antidiuretic action induced by raclopride given intravenously was not affected by renal denervation. Raclopride given into carotid artery was little effect on renal function without relation to renal denervation. Above results suggest that raclopride produces antidiuresis by potentiation of antidiuretic hormone (ADH) action in blood without increase of ADH secretion in posterior pituitary gland, it is not related to renal nerve function in dogs.ogs.s.

Keywords

References

  1. Eur. J. Pharmacol. v.271 no.167 Dopamine receptor antagonist properties of S-14501, 8-OH DPAT, raclopride and chozapine in rodents Protais, P.;Chagrauoui, A.;Arbaoui, J.;Mocaer, E.
  2. Psychopharmacology v.112 no.389 Chronic treatment with the D₁receptor antagonist, SCH 23390 and the D₂receptor antagonist, raclopride, in cebus monkeys withdrawn from previous haloperidol treatment. Extrapyramidol syndroms and dopaminergic super-sensitivity Lublin, H.;Gerlach, J.;Peacock, L.
  3. Neuroscience v.47 no.771 Effect of raclopride on dopamine D₂receptor mRNA expression in rat brain Kopp, J.;Lidefors, N.;Brene, S.;Hall, H.;Person, H.;Sedvall, G.
  4. Life Sci. v.35 no.2281 Two dopamine receptors; Biochemistry, physiology and pharmacology Stoof, J. C.;Kebabian, J. W.
  5. Trends Pharmacol. Sci. v.10 no.74 Mechanism of signal trasduction at the depamine D₂receptor Vallar, L.;Meldolesi, J.
  6. Eur. J. Pharmacol. v.213 no.259 Partial and full dopamine D₁receptor agonists in mice and rats; Relation between behavioural effects and stimulation of adenylate cyclase activity in vitro Arnt, J.;Hyttel, J.;Sanchez, C.
  7. Eur. J. Pharmacol. v.235 no.143 The selective D₁receptor agonist, SKF 8297, stimulates motor behaviour of MPTP-lesioned monkeys Vermeulen, R. J.;Drukarch, B.;Sahadat, M. C. R.;Goosen, D.;Wolters, E. C.;Stoof, J. C.
  8. Eur. J. Pharmacol. v.188 no.335 Dopamine receptor agonists; Selectivity and dopamine D₁receptor efficacy Andersen, P. H.;Jandsen, J. A.
  9. J. Pharmacol. Exp. Ther. v.226 no.462 SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems Iorio, L. C.;Barnett, A.;Leitz, F. H.;Houser, V. P.;Korduba, C. A.
  10. J. Parmacol. v.91 no.153 SCH 23390-The first selective dopamine D₁antagonist Hytell, J.
  11. J. Med. Chem. v.24 no.898 Aporphines 34(-)2,10,11-Trihydroxy-N-n-prophlnoraporphine(TNPA), a novel dopaminergic aporphine alkaloid with anticonvulsant activity Neumeyer, J. L.;Law, S. J.;Medrum, B.;Anlezark, G.;Watling, K. H.
  12. J. Med. Chem. v.33 no.1800 Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues Gao, Y.;Baldessarini, R. J.;Kula, N. S.;Neumeyer, J. L.
  13. 약학회지 v.45 no.205 Dopamine D₂Receptor 효능제인 TNPA의 신장작용 고석태;황명성
  14. 약학회지 v.45 no.397 Dopamine D₂Receptor 효능제인 TNPA의 중추적 항이뇨작용기전 고석태;황명성
  15. J. Clin. Invest. v.56 no.208 Effects of acute unilateral renal denervation in the rat Elsa, B. R.;Rumulo, E. C.;Enrique, P. M.;Robert, A. M.;Carl, W. G.
  16. Quantitative Clinical Chemistry v.2 Methods Phillips, B. A.;Peters(ed.);Slyke(ed.)
  17. J. Clin. Invest. v.21 no.388 The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man Smith, H. W.;Finkelstein, N.;Aliminosa, L.;Crawford, B.;Graber, B.
  18. Statistical Methods(7th ed.) Snedecor, G. W.;Cochran, W. G.
  19. Renal physiology in health and disease Brenner, B.;Coe, F. L.;Rector, F. C. Jr.
  20. 신장학 호남신장학회
  21. Principles of Renal Physiology(4th Ed) Smith, H. W.
  22. Goodman & Gilman's The Pharmacological Basis of Therapeutics(9th Ed.) Hardman, J. G.;Limbird, L. E.;Molinoff, P. B.;Ruddon, R. W.;Gilman, A. G.
  23. J. Clin. Invest. v.81 no.1879 Calcium and cyclic adenosine monophosphate as second messenders for vasopressin in the rat inner medullary collecting duct Star, R. A.;Nomoguchi, H.;Balaban, R.;Knepper, M. A.
  24. Am. J. Physiol. v.259 no.F823 c-AMP mediates the increase in apical membrane Na+ conductance produced in rat CCD by vasopressin Schafer, J.;Troutman, S.
  25. Am. J. Physiol. v.229 no.60 Renal neuroadrenergic transmission Slick, G. L.;Agilera, A. J.;Zambrack, E. J.;DiBona, G. F.;Kaloyanides, G. F.
  26. Physiology of the Kidney and Body Fluids Pitts, R. T.
  27. Am. J. Physiol. v.223 no.1201 Effects of renal alpha-adrenergic stimulation on proximal tubular sodium reabsorption Gill, J. R.;JR.;Caster, A. G. T.