YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Distribution and Characterization of Heavy Metals in Human Kidney Cortex and Kidney Medulla

인체 신장피질과 신장수질에서 중금속류의 분포 및 특성

  • Published : 2001.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Heavy metals, such as Al, As, Cd, Cr Cu, Fe, Hg, Mn, Mo, Ni, Pb, Se, Si, Sn, V and Zn, were analysed on kidney cortex and medulla of Korean obtained from 154 forensic medical autopsy cadavers. Heavy metals were analysed by inductively coupled plasma atomic emission spectrometry In kidney cortex, the concentrations of Al, Cd, Cu, Mn, Mo, Pb, Se, Si and Zn were significantly higher than in the kidney medulla (Cd, Cu, Mn, Mo, Zn : p<0.01, AA, Pb, Se, Si : p<0.05). No significant local differences were found between kidney cortex and kidney medulla in the concentrations of As, Cr Fe, Hg, Ni, Sn and V. In kidney cortex and kidney medulla, Cd concentrations correlated positively with age, but Mn concentrations correlated negatively with age. A significantly positive correlation between Cd and Zn, Cd and Cu, Zn and Cu, Al and Si, Se and As was found in kidney cortex and kidney medulla. A significantly positive correlation between Hg and Se was only observed in kidney cortex. These results indicate that the distribution of hazardous heavy metals is similar to that of essential elements in the tissues.

Keywords

References

  1. Critical Rev.Env.Contr. v.2 no.517 Mercury pollution:The making of an environmental crises Katz,A
  2. J.Trace Elem.Electrolytes Health Dis. v.2 no.101 Selenium,zinc,copper and cadmium concentration in livers and kidneys of people exposed to environmental cadmium Kido,T.;Tsuritani,I.;Honda,R.;Yamaya,H.;Ishizaki,M.;Yamada,Y.;Nagawa,K.
  3. Sci.Total Environ. v.91 no.127 Interrela-tionship between the concentrations of some elements in the organs of Japanese with special reference to selenium-heavy metal relationships Yoshinaga,J.;Matsuo,N.;Imai,H.;Nakazawa,M.;Suzuki,T.;Morita,M.;Akagi,H.
  4. Biol.Trace Elem.Res. v.63 no.167 Age-dependent changes in metallothionein levels in liver and kidney of the Japanese Yoshida,M.;Ohta,H.;Yamauchi,Y.;Seki,Y.;Sagi,M.;Yamazaki,K.;Sumi,Y.
  5. Sci.Total Environ. v.170 no.53 Cadmium and zinc relationships in the river and kidney of humans exposed to environmental cadmium Torra,M.;To-Figueras,J.;Rodamilans,M.;Brunet,M.;Corbella,J.
  6. Cancer Chemother Pharmacol. v.34 no.14 Factors affecting human autopsy kidney cortex and kidney medulla platinum concentrations after cisplatin administration Stewart,D.J.;Dulberg,C.;Molepo,J.M.;Mikhael,N.Z.;Montpetit,V.A.;Redmond,M.D.;Goel,R.
  7. Eur.J.Cancer Prev. v.3 no.45 Levels of cadmium,zinc and copper in renal cell carcinoma and normal kidney Hardell,L.;Wing,A.M.;Ljungberg,B.Dreifaldt,A.C.;Degerman,A.;Halmans,G.
  8. Zentralbl.Bakteriol.Mikrobiol.Hyg.[B] v.187 no.18 The cadmium content of human tissues from biopsies Angerer,P.;Kessel,R.;Bencze,K.;Tewordt,M.;Mauermayer,R.;Friesen,A.
  9. Hum.Toxicol. v.6 no.111 Cadmium concentrations in human kidneys from the UK. Scott,R.;Aughey,E.;Fell,G.S.;Quinn,M.J.
  10. Zentralbl.Bakteriol.Mikrobiol.Hyg.[B] v.182 no.33 Cadmium concentrations in autopsy material from differently polluted areas of West Germany(FRG) Thurauf,J.;Schaller,K.H.;Valentin,H.;Weltle,D.;Grote,K.;Schellmann,B.
  11. Environ.Res. v.39 no.1 Distribution and concentration of cadmium in human kidney Svartengren,M.;Elinder,C.G.;Friberg,L.;Lind,B.
  12. Urol.Res. v.14 no.105 Studies of Cd,Zn and Cu levels in human kidney tumours and normal kidney. Feustel,A.;Wennrich,R.;Dittrich,M.
  13. Med.Sci.Law v.18 no.155 Mercury and lead content of human body tissues from a selected population Schmidt,R.;Smith,H.
  14. Arch.Environ.Health. v.17 no.881 Essential and nonessential trace elements.A method of determining whether an element is essential or nonessential in human tissue Liebscher,K.;Smith,H.
  15. Arch.Environ.Health v.30 no.487 Heavy metals in normal Japanese tissues Sumino,K.;Hayakawa,K.;Shibata,T.;Kitamura,S.
  16. Arch.Environ.Health. v.35 no.36 Distribution of Trace Elements in the Human Body Determined by Neutron Activation Analysis Yukawa,M.;Amano,K.;Yasumoto,M.S.;Terai,M.
  17. Evaluation and Statistics v.73 Neutron Activation Analysis of trace elements in human organs Yamamoto,Y.;Ushiyama,I.;Nishi,K.
  18. Gesund-heitswesen v.56 no.263 Comparison of the burden of the population in the region of Leipzig and Munich with the Heavy metals cadmium,lead and mercury-an investigation on human tissues Drasch,G.;Muler,R.K.;Grasemann,F.;Adang,M.;Roider,G.;Wowra,D.
  19. J.Reprod.Fertil. v.99 no.421 Concentrations of lead cadmium and zinc in the tissues of reproductive organs of men Oldereid,N.B.;Thomassen,Y.;Attramadal,A.;Olaisen,B.;Purvis,K.
  20. Scu.Total Environ. v.138 no.101 The relationship between mercury concentration in human organs and different predictor variables Weiner,J.A.;Nylander,M.
  21. Nature v.245 no.385 Mercuryselenium correlations in marine mammals. Koeman,J.H.;Peeters,W.H.M.;Koudstaal-Hol,C.H.M.;Tjioe,P.S.;de Goeji,J.J.M.
  22. Sci.Total Environ. v.3 no.279 Mercury and selenium in marine mammals and birds Koeman,J.H.;van de Ven,W.S.M.;de Goeji,J.J.M.;Tjioe,P.S.;van Haaften,J.L.
  23. Arctic.Sci.Total Environ v.48 no.195 Heavy metals and essential elements in livers of the polar bear(Ursus maritimus) in the Canadian Norstrom,R.J.;Schweinberg,R.E.;Collins,B.T.
  24. Bull.Environ.Contam.Toxicol. v.19 no.273 Mercury and selenium contents of seals from fresh and brackish waters in Finland Kari,T.;Kauranen,P.
  25. 인체장기 조직중 미량 유해 금속 원소의 신속 정량법에 관한 연구 v.30 no.33 유영찬
  26. Arch.Environ.Health v.44 no.298 Mercury concentration in organs of contemporary Japanese Matsuo,N.;Suzuki,T.;Akagi,H.
  27. Arch.Environ.Health v.29 no.18 Mercury Burdon of Human Autopsy Organs;Tissues Norman,K.M.;Ralph,L.B.
  28. J.Anal.Toxicol. v.5 no.90 Mercury and selenium content and chemical form in human and animal tissue Cappon,C.J.;Smith C.
  29. Clin.Chem. v.18 no.67 Measurement and distribution of zinc,cadmium,and mercury in human kidney tissue Livingston,H.D.
  30. Arch.Environ.Health v.31 no.292 Cadmium in kidney cortex,liver and pancreas from Swedish autopsies Elinder,C.G.;Kjelstrom,T.;Friberg,L.;Lind,B.;Linnman,L.
  31. Environ.Health Perspect. v.28 no.169 Exposure and accumulation of cadmium in populations Kjellstrom,T.
  32. Bull.Environ.Contam.Toxicol. v.23 no.627 Cadmium concentrations in human kidney and liver tissues from western Australia Spickett,J.T.;Lazner,J.
  33. J.Kumamoto Med.Sci. v.34 no.383 Analytical studies on methylmercury in animal organs and foodstuffs. Ujioka,T.