Parasites, Hosts and Diseases
- 제39권2호
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- Pages.143-150
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- 2001
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- 2982-5164(pISSN)
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- 1738-0006(eISSN)
Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates
- Kho, Weon-Gyu (Department of Parasitology, Institute of Malariology, Inje University College of Medicine) ;
- Chung, Joon-Yong (Department of Parasitology, Institute of Malariology, Inje University College of Medicine) ;
- Sim, Eun-Jeong (Department of Parasitology, Institute of Malariology, Inje University College of Medicine) ;
- Kim, Dong-Wook (Department of Internal Medicine Inje University College of Medicine) ;
- Chung, Woo-Chul (Department of Internal medicine, Catholic University College of Medicine)
- 발행 : 2001.06.01
초록
The present study was designed to investigate polymorphism in Duffy binding protein (DBP) gene of Plasmodium vivax isolates of Korea. Thirty samples were obtained from P. vivax patients in Yonchon-gun, Kyonggi-do in 1998. The PCR products of the samples were subjected to sequencing and hybridization analyses of the regions II and IV of P. vivax DBP gene. Two genotypes, SK-1 and SK-2, were identified on the basis of amino acid substitution and deletion. The genotype of 10 isolates was SK-1 and that of 20 isolates was SK-2. Most of the predicted amino acids in the region ll of DBP gene were conserved between the Korean isolates and Belem strain except for 4-5 amino acid substitutions. In the region W of DBP, a 6-bp insert that was shown in the Sal-1 allele type was found in SK-1, and a 27-bp insert that was shown in the Papua New Guinea allele type was found in SK-2. In conclusion, the present findings suggest that two genotypes of P. vivax coexist in the endemic area of Korea.