Biomolecules & Therapeutics
- Volume 9 Issue 3
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- Pages.183-187
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- 2001
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
Inhibitory Activity of Chinese Medicinal Plants on Nitric Oxide Synthesis in Lipopolysaccharide -Activated Macrophages
- Ryu, Jae-Ha (College of Pharmacy, Sookmyung Women′s University) ;
- Ahn, Han-Na (College of Pharmacy, Sookmyung Women′s University) ;
- Lee, Hwa-Jin (College of Pharmacy, Sookmyung Women′s University) ;
- Feng, Li (Guangxi Institute of Botany) ;
- Qun, Wen-He (Guangxi Institute of Botany) ;
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
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Han, Byung-Hoon
(Natural Products Research Institute, Seoul National University)
- Published : 2001.09.01
Abstract
Nitric oxide (NO) produced in large amounts by the inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of Chinese medicinal plants and screened their inhibitory activity against NO production in lipopolysaccharide (LPS)-activated macrophages. Among the 80 kinds of extracts of herbal drugs, 15 extracts showed potent inhibitory activity of NO production above 80% at the concentration o