Abstract
Another approach (multi-parameter measurement method) of interlaboratory studies of test methods is presented. When the unrestricted normal likelihood for the fixed latent variable model is unbounded, we propose a me쇙 of restricting the parameter space by formulating realistic alternative hypothesis under which the likelihood is bounded. A simulation study verified the claim of conservatism of level of significance based on assumptions about central chi-square distributed test statistics and on Bonferroni approximations. We showed a randomization approach that furnished empirical significance levels would be better than a Bonferroni adjustment.
