Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effect of Thesium Chinese Turczaninow Aqua-acupuncture Solution and Astragail Radix Aqua-acupuncture Solution on Promotion/ progression of Carcinogenesis

하고초와 황기 약침액이 발암 진행과정에 미치는 영향

  • 손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터) ;
  • 박신화 (동국대학교 한의과대학 경혈학교실) ;
  • 류준선 (동국대학교 한의과대학 경혈학교실) ;
  • 조경희 (동국대학교 한의과대학 경혈학교실) ;
  • 임종국 (동국대학교 한의과대학 경혈학교실) ;
  • 남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구센터)
  • Published : 2001.08.01
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Abstract

Cancer chemoprevention refers to the use of natural or synthetic substances to prevent initiational and promotional events that occur during the process of carcinogenesis. Thesium Chinese Turczaninow aqua-acupuncture solution (TCTAS) and Astragli Radix aqua-acupuncture solution (ARAS) were tested as the cancer chemopreventive agents using biochemical markers of carcinogenesis. The effects on the inhibition of phorbol 12- myristate 13-acetate(TPA)-induced free radical formation in HL-60 cells and the inhibition of polyamine metabolism were measured. There is significant inhibition of TAP-induced free radical formation in human leukemic cells with cells with ARAS. Proliferation of Acanthamoeba castellanii was inhibited by TCTAS and ARAS. TCTAS and ARAS positive in these assays may inhibit the carcinogenesis process and is considered promising cancer-preventing agents.

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