Biotechnology and Bioprocess Engineering:BBE

  • 제6권1호
  • /
  • Pages.42-50
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  • 2001
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  • 1226-8372(pISSN)
  • /
  • 1976-3816(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
권호 표지

Rigorous Model for Spherical Cell-support Aggregate

  • Moon, Seung-Hyeon (Department of Environmental Science and Engineering, Kwangju Institute of Science and Technology) ;
  • Lee, Ki-Beom (Department of Environmental Science and Engineering, Kwangju Institute of Science and Technology) ;
  • Satish J. Paruekar (Department of Chemical and Environmental Engineering, Illinois Institute of Technology)
  • 발행 : 2001.01.01
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초록

The activity of immobilized cell-support particle aggregates is influenced by physical and biochemical elements, mass transfer, and physiology. Accordingly, the mathematical model discussed in this study is capable of predicting the steady state and transient concentration profiles of the cell mass and substrate, plus the effects of the substrate and product inhibition in an immobilized cell-support aggregate. The overall mathematical model is comprised of material balance equations for the cell mass, major carbon source, dissolved oxygen, and non-biomass products in a bulk suspension along with a single particle model. A smaller bead size and higher substrate concentration at the surface of the particle, resulted in a higher supply of the substrate into the aggregate and consequently a higher biocatalyst activity.

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참고문헌

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