Journal of Gastric Cancer
- 제1권1호
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- Pages.10-16
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- 2001
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- 2093-582X(pISSN)
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- 2093-5641(eISSN)
위선암종의 예후인자로서 p53, CD44v6과 VEGF 단백 발현
Expression of p53, CD44v6 and VEGF in Gastric Adenocarcinomas
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박언섭
(중앙대학교 의과대학 병리학교실) ;
- 이창영 (중앙대학교 의과대학 병리학교실) ;
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이태진
(중앙대학교 의과대학 병리학교실) ;
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김미경
(중앙대학교 의과대학 병리학교실) ;
- 유재형 (중앙대학교 의과대학 병리학교실)
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Park, Eon-Sub
(Department of Pathology, College of Medicine, Chung-Ang University) ;
- Lee, Chang-Young (Department of Pathology, College of Medicine, Chung-Ang University) ;
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Lee, Tae-Jin
(Department of Pathology, College of Medicine, Chung-Ang University) ;
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Kim, Mi-Kyung
(Department of Pathology, College of Medicine, Chung-Ang University) ;
- Yoo, Jae-Hyung (Department of Pathology, College of Medicine, Chung-Ang University)
- 발행 : 2001.03.01
초록
Purpose: The p53 protein is a tumor supressor gene, and its mutation is associated with biologic aggressiveness. CD44v6, one of the CD44 family, is a cell surface glycoprotein that plays a role in cancer invasion and metastasis. Vascular endothelial growth factor (VEGF) is another recently identified growth factor with significant angiogenic properties. The purpose of this study was to investigate p53, CD44v6, and VEGF expressions to determine whether degree of expression was related to pathological parameters such as Lauren's classification, depth of invasion, and lymph node metastasis. Materials and Methods: Immunohistochemical stains of p53, CD44v6, and VEGF in formalin-fixed paraffin-embedded tissue sections of 125 gastric adenocarcinomas were done. Results: The overall expression rates of p53, CD44v6, and VEGF were