Radiation Oncology Journal
- 제19권2호
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- Pages.181-189
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- 2001
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
C57BL/96 Mouse의 폐, 간, 신장에서 방사선조사 후 TIMP-1, TIMP-2의 발현에 대한 면역조직화학적 연구
Immunohistochemical Studies for TIMP-1 and TIMP-2 Expression after Irradiation in Lung, Liver and Kidney of C57BL/6 Mouse
- 노영주 (울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
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안승도
(울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
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김종훈
(울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
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최은경
(울산대학교 의과대학 서울중앙병원 방사선종양학과) ;
- 장혜숙 (울산대학교 의과대학 서울중앙병원 방사선종양학과)
- Noh, Young-Ju (Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
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Ahn, Seung-Do
(Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
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Kim, Jong-Hoon
(Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
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Choi, Eun-Kyung
(Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan) ;
- Chang, Hye-Sook (Department of Radiation Oncology, Asan Medical Center, College of Medicine, University of Ulsan)
- 발행 : 2001.06.01
초록
목적 : 피부나 폐, 간, 신장 등의 섬유화가 방사선 조사 후 주요한 부작용 중의 하나이나 아직까지 이 과정에서
Purpose : Changes in the balance between MMP and TIMP can have a profound effect on the composition in the extracellular matrix (ECM) and affect various cellular functions including adhesion, migration, differentiation of cells, and fibrosis and invasion and metastasis of cancer cells. Radiation therapy is a popular treatment modality for benign and malignant tumor, but the study for radiation effect on MMP and TIMP is scarce. In the current study, we have examined the expression of TIMP in fibrosis-prone (C57BL/6) mice after radiation. Methods and Materials : Adult female mice of