Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Effect of Gami-Ondamtang(GO) on brain neuronal transmitters in immobilized rats

가미온담탕(加味溫膽湯)이 스트레스성 뇌신경전달물질(腦神經傳達物質) 변화(變化)에 미치는 영향(影響)

  • Kang Tak-Lim (College of Oriental medicine, Taejeon University)
  • 강탁림 (대전대학교 한의과대학)
  • Published : 2001.12.29
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Abstract

To elucidate the preventive effect of oriental medicine Gami-Ondamtang(GO) on stress, we investigated the physiological change of rats which were applied immobilization stress. For immobilization stress, rats were placed in restrainer for 12 hours a day for 3 days. During application of stress, body weight of rats was measured. After sacrifice, 8 organs were taken for measurement of organ weight. Brain was sectioned into 4 parts that are Frontal Cortex, Corpus Striatum, Hypothalamus and Hippocampus. Each part was homogenated and its catecholamine and serotonin contents were measured with HPLC. In our study, stress mainly induced increase of concentration of neurotransmitters in brain without other significant physical change of rats. GO inhibited stress induced changes of neurotransmitter content in brain.

Keywords

References

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