동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제12궈1호
  • /
  • Pages.137-149
  • /
  • 2001
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

세심탕(洗心湯)에 의한 뇌(腦) 성상세포(星狀細胞)로부터 염증성(炎症性) 세포활성물질(細胞活性物質)의 분필(分泌) 억제(抑制) 효과(效果)

Studies on Inhibitory Effect of inflammatory Cytokines Secretion from Brain Astrocytes by Sesim-Tang

  • 김태헌 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김준한 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실)
  • Kim Tae-Heon (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Kim Jun-Han (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Lyu Yeoung-Su (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University) ;
  • Kang Hyung-Won (Dept. of Neuropsychiatry, College of Oriental Medicine, Won Kwang University)
  • 발행 : 2001.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Cytokines are polypeptides which possess various biological properties affecting. host defense function and response to disease. Inflammatory cytokines, tumor necrosis $factor-{\alpha}$(TNF-${\alpha}$), interleukin(IL)-1 and IL-6 induce inflammation, fever, hypotension and pain when injected into animals or human subject. When glial cell cultures were prepared from neonatal mice or rats, astrocytes were reported to produce these inflammatory cytokines to viral infection, lipopolysaccharide(LPS), or cytokines. The purpose of this study was to investigate the regulatory effect of these cytokines secretion from primary cultures of rat astrocytes. Substance P(SP) can stimulate secretion of TNF-${\alpha}$ from astrocytes stimulated with LPS. Sesim-Tang significantly inhibited the TNF-${\alpha}$ secretion by astrocytes stimulated with SP and LPS. IL-1 has been shown to elevate TNF-${\alpha}$ secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore also investigated whether IL-1 mediated inhibition of TNF-${\alpha}$ secretion from primary astrocytes by Sesim-Tang. Treatment of Sesim-Tang to astrocytes stimulated with both LPS and SP decreased IL-1 secretion significantly. The secretion of TNF-${\alpha}$ by LPS and SP in astrocytes was progressively inhibited with increasing amount of IL-1 neutralizing antibody. Furthermore Sesim-Tang inhibited the IL-6 secretion by astrocytes stimulated with SP and LPS. The inhibitory effect of inflammatory cytokines by Sesim-Tang, observed in this study, might reflect an antiinflammatory activity and a reduction of various-type pains, fever etc. in the central nervous system.

키워드

참고문헌

  1. 中醫 雜誌 v.4 眞氣와 養生抗老化 魏明(外)
  2. 中醫精神醫學 李淸福;劉渡舟(編)
  3. 東醫精神醫學 黃義完(外)
  4. 最新臨床精神醫學 이근후
  5. Science v.241 Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Lotz, M.;Vaughan, J.H.;Carson, D.A.
  6. Proc. Natl. Acad. Sci. USA v.86 Substance P receptor binding sites are expressed by glia in vivo after neuronal injury. Manthy, P.W.;Johnson, D.J.;Boehmer, C.G.;Catton, M.D.;Vinters, H.V.;Maggio, J.E.;Too, H.P.;Vigna, S.R.
  7. Funct. Neurol. v.14 no.3 Proinflammatory cytokines in cervicogenic headache. Martelletti, P.;Stirparo, G.;Giacovazzo, M.
  8. 國譯辨證奇聞 陳士擇
  9. J. Immunol. v.129 Production of prostaglandin E and an interleukin-1 like factor by clutured astrocytes and C-6 glioma cells. Fontana, A.;Kristensen, F.;Dubs, R.;Gemsa, D.;Webew, E.
  10. Lancet v.2 Raised serum levels of tumor necrosis factor in parasitic infections. Scuderi, P.Sterling, K.E.;Lam, K.S.;Finley, P.R.;Ryan, K.J.;Ray, C.G.;Petersen, E.;Slymen, D.J.;Salmon, S.E.
  11. J. Immunol. v.152 Substance P enhances the secretion of tumor necrosis factor-a from neuroglial cells stimulated with lipopolysaccharide. Luber-Narod, J.;Kage, R.;Leeman, S.E.
  12. J. Neuroimmunol. v.36 Interleukin-1 beta induction of tumor necrosis factor-alpha gene expression in human stroglioma cells. Bethea, J.R.;Chung, I.Y.;Sparacio, S.M.;Gillespie, G.Y.;Benveniste, E.N.
  13. 한국통계연감 no.38 통계청
  14. 神經精神醫學 v.34 no.3 老人精神障碍患者의 추적 治療實態에 대한 考察 신명기(外 2人)
  15. 黃帝內經譯解(素問) 楊維傑(編)
  16. 黃帝內經譯解(靈樞) 楊維傑(編)
  17. 本草綱目 李時珍
  18. 醫林改錯 王淸任
  19. 北京中醫學大學學報 v.19 no.6 略論張錫純心腦共主神明說 程如海
  20. 成人病 老人病學 徐舞圭
  21. 黃帝內經靈樞解釋 洪元植(譯)
  22. 黃帝內經素問解釋 洪元植(譯)
  23. 傳統老年醫學 李聰甫(外)
  24. Immunol. Rev. v.100 Immune-mediated encephalitis; on the role of antigen-presenting cells in brain tissue. Fontana, A.;Frei, K.;Bodmer, S.;Hofer, E.
  25. Brain Res.(Mol. Brain Res.) v.16 Expression of amyloid precursor protein mRNAs in endothelial. neuronal. and glial cells: modulation by interleukin-1. Forloni, G.;Demicheli, F.;Giorgi, S.;Bendotti, C.;Angeretti, N.
  26. Ann. Neurol. v.23 Tumor necrosis factor mediates myelin and okigodendrocyte damage in vitro. Selmaj, K.W.;Raine, C.S.
  27. Neuroscience v.98 no.3 Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Honore, P.;Roger, S.D.;Schwei, M.J.;Salak-Johnson, J.L.;Luger, N.M.;Sabino, M.C.;Clohisy, D.R.;Manthy, P.W.
  28. Neuroroport. v.11 no.3 Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model. DeLeo, J.A.;Rutkowski, M.D.;Stalder, A.K.;Campbell, I.L.
  29. Adv Prostaglandin Thromboxane Leukot Res v.21B Marriott, D.;Wilkin, G.P.;Coote, P.R.;Wood, J.N.
  30. 東醫神經 精神科學會誌 v.9 no.1 天門冬에 의한 腦神經細胞로부터 炎病性 細胞活性物質 分泌의 抑制 效果 姜亨沅
  31. 國譯 景岳全書 第三冊 張介賓
  32. 國譯石室秘錄 陣士鐸
  33. 辨證奇聞全書 錢鏡湖
  34. 編註醫學入門(卷二) 李천
  35. 實用中醫內科學 黃大東(外)
  36. 東醫神經精神科學會誌 v.7 no.1 記憶障礙에 關한 東$\cdot$西醫學的 比較, 硏究 柳泳秀(外)
  37. 大韓韓醫學會誌 v.17 no.1 健忘의 辨證分型에 對한 硏究 崔龍埈
  38. 大韓鍼灸學會誌 v.14 no.2 痴呆治療의 最近 硏究動向에 關한 考察 金利和(外)
  39. 東醫神經精神科學 會誌 v.8 no.1 調胃升淸湯이 흰쥐의 방사형 미로 학습과 기억에 미치는 영향 우주영(外)
  40. 東醫神經精神科學會誌 v.8 no.2 洗心湯이 腦組織의 酸化作用에 미치는 影響 金聖賢
  41. 東醫神經精神科學會誌 v.10 no.1 遠志에 의한 腦 星狀細胞로부터 炎病性 細胞活性物質 分泌의 抑制 效果에 關한 硏究 黃始榮
  42. 申氏本草學 申佶求
  43. Proc. Natl. Acad. Sci. USA v.83 Substance P receptors in primary cultures of cortical astrocytes from the mouse. Torrens, Y.;Beaujouan, J.C.;Saffroy, M.;Daguet de Montety, M.C.Bergstrom, L.;Glowinski, J.
  44. j. Neurosci. v.8 interleukin-1 injection into mammalian brain stimulates astrogliosis and neovascularization. Giulian, D.;Woodward, J.;Young, D.G.;Krebs, J.F.;Achman, L.B.
  45. J. Neuroimmunol. v.38 In vivo relationship of tumor necrosis factor-a to blood-brain barrier damage in patients with active multiple sclerosis. Sharief, M.K.;Thompson, E.J.
  46. J. Immunol. v.144 Tumor necrosis factor-alpha production by astrocytes: induction by lipopolysaccharide, interferon-gamma and interleukin-1. Chung, I.Y.;Benveniste, E.N.