성장치료를 위한 한약투여의 임상적 효과 및 안전성 평가

The Feasibility and Safety of Herbal Medication on Short Stature

  • 정정욱 (분당차한방병원 한방내과) ;
  • 양태규 (분당차한방병원 한방내과) ;
  • 구본홍 (강남차한방병원 한방내과) ;
  • 이세연 (분당차한방병원 한방내과)
  • Cheong, Jeong-Ook (Department of Internal Medicine, Pundang CHA Oriental Hospital) ;
  • Yang, Tae-Kyu (Department of Internal Medicine, Pundang CHA Oriental Hospital) ;
  • Koo, Bon-Hong (Department of Internal Medicine, Kangnam CHA Oriental Hospital) ;
  • Lee, Sea-Yun (Department of Internal Medicine, Pundang CHA Oriental Hospital)
  • 발행 : 2001.12.30

초록

Objective : Recently many studies of herbal medication to promote growth have been implemented. The purpose of this study was to identify the feasibility and safety of herbal medication on short stature. Methods : 143 patients(87 males, 56 Females)who visited with short stature at Kangnam CHA Oriental Hospital From February 1999 to January 2000 and were treated during 6 months, were available for this study. We treated with 5 herbal medications.(Soeumin hyangbujapalmultang-gagambang, Soyangin yukmijihwangtang-gagambang, Taeumin chungsimyunjatang-gagambang, Boa-tang, Boikyangwi tang) At the begining of the treatment and after 6 months treatment, We measured height, weight and body mass index(BMI). And we investigated changes of aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN), alkaline phosphatase(ALP), creatinine. Results: The distribution of ages was from 5 years old to 17 years old. After herbal treatment, mean height, mean weight, mean BMI and mean percentile grade increased $138.5{\pm}15.6$ to $141.9{\pm}15.1$, from $36.9{\pm}13.2$ to $38.9{\pm}13.2$, from $18.5{\pm}3.29$ to $18.7{\pm}3.21$, from $3.2{\pm}1.2$ to $3.4{\pm}1.2$. The contents of AST, ALT, BUN, ALP and Creatinine were not showed any significant change. Conclusions : In the results We recognized Short stature was showed prominent feasibility and safety of herbal medication. Herbal Medication in patients with short stature will improve height velocity without liver and kidney function disorders.

키워드

참고문헌

  1. 대한한방소아과학회지 v.11 no.1 成長障碍에 關한 文獻的 考察 장규태;김장현
  2. 소아과학회 v.36 no.5 왜소증의 진단 및 치료 김덕희
  3. 소아과학회지 v.39 no.9 성장장애의 진단과 치료 신재훈
  4. 소아과학회지 v.37 no.4 비기질적인 성장장애 환아에 관한 연구 이근
  5. Current Opinion in Pediatrics v.10 no.4 Growth hormone therapy for nongrowth hormon-deficient children whith short stature Guyda, H.J.
  6. Arch Dis Child v.84 no.4 Final height of short subjects of low birth weight with and without growth hormone treatment Zucchini, S.;Cacciari, E.;Balsamo, A.;Cicognani, A.;Tassinari, D.;Barbieri, E.(et al.)
  7. Am J Med Genet v.99 no.2 Long-term treatment with growth hormone improves final height in a patient with Pallister-Hall syndrome Galasso, C.;Scire, G.;Fabbri, F.;Spadoni, G.L.;Kiloran, C.E.;Biesecker, L.G.(et al.)
  8. Natl Med J India v.11 no.5 Use of growth hormone in non-growth hormone deficient children Sood, A.;Menon, P.S.
  9. Current Opinion in Pediatrics v.12 no.4 Genetic studies in idiopathic short stature Attie, K.M.
  10. 한국본초학연구회지 v.1 no.1 韓藥 성장단이 흰쥐의 成長호르몬 分泌촉진에 미치는 효과 배오성;김호철;안덕균
  11. 대한한방소아과학회지 v.12 no.1 韓藥複合製劑의 투여가 돼지의 성장 및 성장호르몬 분비에 미치는 영향 구본홍;이태업;이병우
  12. 대한한방소아과학회지 v.12 no.1 成長障碍에 關한 臨床的 硏究 김장현
  13. 대한한방소아과학회지 v.12 no.1 成長障碍를 主訴로 來院한 患兒의 治療效果에 대한 考察 이동현;김덕곤
  14. 대전대논문집 v.7 no.2 성장장애를 주소로 내원한 환아 200예에 대한 임상적 관찰 나동규
  15. 대한한방내과학회지 v.20 no.2 한약과 양약의 장기간 사용에서 발생한 급성약물 중독성 간염 치험1례 고홍;홍석철
  16. 경희의학 v.14 no.2 한약의 장기투여가 간손상에 미치는 영향 김영석;노진환;문상관;조기호;배형섭;이경섭
  17. 대한한방내과학회지 v.21 no.2 증례를 통해 본 한약투여가 간손상 환자의 간손상에 미치는 영향 김태식;정한수;정희