대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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제조가 초산납으로 유발한 흰쥐의 뇌독성에 미치는 영향

Effect of Holotrichia in Brain of Lead Acetate-treated Rats

  • 윤종영 (동국대학교 한의과대학 내과학교실) ;
  • 민건우 (동국대학교 한의과대학 내과학교실) ;
  • 신정인 (동국대학교 한의과대학 내과학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 서운교 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 신억섭 (동국대학교 의료원 약제과) ;
  • 박종혁 (동국대학교 한의과대학 내과학교실)
  • Yoon, Jong-Young (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Min, Gun-Woo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin, Jeong-In (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Seo, Un-Kyo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin, Uk-Seob (Dept. of Pharmacy Dongguk Medical Center, Dongguk University) ;
  • Park, Jong-Hyuck (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 발행 : 2001.09.30
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초록

Objectives: This study was undertaken to investigate the action mechanism of Holotrichia (HT) at parameter related to dementia. Methods: HT was tested for the effects on acetylchonine esterase and monoamine oxidase activities, lipid peroxidation, antioxidation in brain of lead acetate-treated rats. Lead acetate were treated firstly into samples for 10 days, and then lead acetate and HT were set with them for 20 days. Results: The level of lipid peroxide, acetylcholine esterase and monoamine oxidase activities, enzyme activities and ratio of type conversion of xanthine oxidase increased in lead acetate-treated rats were decreased as highly as normal group by HT. Superoxide dismutase, catalase and glutathione peroxidase activities, the level of acetylcholine decreased in lead acetate-treated rats were increased as lowly as normal group by HT. Conclusions : These results suggest that HT might have an effect on treatment of dementia according to decreasing the activities of acetylcholine esterase, monoamine oxidase and level of lipid peroxide in brain.

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