The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Studies on the Effect and Mechanism of Geupoongjibo-dan's Relaxation on a Blood Vessel

거풍지보단(祛風至寶丹)의 혈관이완 효능과 기전에 관한 연구

  • Kim, Dong-Eun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Park, Dong-Wan (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Sung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin, Gil-Cho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Won-Chul (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Han, Sung-Ho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 김동은 (동국대학교 한의과대학 내과학교실) ;
  • 박동완 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 한성호 (동국대학교 한의과대학 내과학교실)
  • Published : 2001.06.30
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Abstract

Objectives : This study was conducted to evaluate the effect and mechanism of Geupoongjibo-dan's relaxation of the tension of the blood vessel caused by Phenylephrine and KCI. Methods : In order to study the effect of Geupoongjibo-dan's relaxation of the blood vessel tension, Geupoongjibo-dan extract was infused into Phenylephrine and KCI-induced contracted rabbit aorta strips. To analyze the mechanism of Geupoongjibo-dan's effect on the blood vessel, Geupoongjibo-dan extract infused into Phenylephrine and KCI-induced contracted strips induced by agonists after treatment of N${\omega}$-nitro-L-arginine, Methylene Blue. Results : 1. Geupoongjibo-dan was very effective in relaxing the blood vessels contracted by Phenylephrine. 2. Geupoongjibo-dan was effective against Phenylephrine, than against KCI. 3. Geupoongjibo-dan's more relaxation effect on a blood vessel was terminated by N${\omega}$-nitro-L-arginine and methylene treatment. Conclusion : THis study showed that Geupoongjibo-dan's relaxation effect on a blood vessel is irrelevant to ${\alpha}$-adrenalin receptor, and it relaxes contracted vessels through cGMP channel.

Keywords

References

  1. 慶熙醫學 v.13 no.2 高血壓및 高指血症에 대한 天麻丸의 실험적 연구 姜俊權;文祥官;高昌男;曺基湖;金永錫;裵亨燮;李亨燮
  2. 내과학의 최신지견I 민영일(편저)
  3. Management of hypertensive crises Gifford RW Jr.
  4. 내과학 최신지견II 서울대학교 의과대학 내과학교실
  5. 慶熙醫學 v.13 no.1 輕症 高血壓 治療에 對한 東西醫學的 接近試圖 曺基湖;高成奎;文祥官;高昌男;金永錫;裵亨燮;李亨燮
  6. 實用中醫內科手冊 蔡감(主編)
  7. 實用中醫結合臨床指南 張駿;鄭福星(主編)
  8. 中西醫辨症診治 白洪龍
  9. 高血壓病中醫獨特療法 張俊龍;肖飛
  10. 丹溪心法 朱震亨
  11. 東醫寶鑑 許浚
  12. 醫方集解 汪訊庵
  13. 東醫方劑와 處方解說 尹用甲
  14. 東醫生理學會誌 v.11 no.2 龍膽瀉肝湯이 家兎 血管平滑筋의 緊張性 調節에 미치는 影響 孟仙淑;申與黙;金吉萱
  15. 東醫生理學會誌 v.10 no.1 ??이 家兎의 血管內皮細胞性 弛緩因子에 미치는 影響 金昊顯;申與默;金吉萱
  16. 東國大學校 大學院 韓醫學科 三種 黃連類의 血管弛緩 作用에 關한 比較實驗 硏究 李敬愛
  17. 大韓韓醫學會誌 v.12 no.1 防風通聖通散이 高血壓, 高脂血에 미치는 영향 李南勳;辛吉祚;曹基湖;金永錫;裵亨燮;李亨燮
  18. 東國大學校 大學院 祛風至聖寶丹이 Mongolian Gerbil의 가역성 전뇌허혈 모델에 미치는 영향 鄭完祐
  19. 實用中西醫結合診斷治療學 陳貴延(主編)
  20. 實用內科學 上海第一學院
  21. 臟腑辨證論治 金完熙;崔達永
  22. 中醫內科學 上海中醫學院(編)
  23. 大韓韓方小兒科學會誌 v.12 no.1 羌活이 家兎 血管平滑筋의 緊張性 調節에 미치는 影響 張奎台
  24. 實用中醫內科學 方藥中;鄭鐵濤;李克光;金壽山;黃星垣;董建華
  25. Medical Physiology no.20 Guyton, A.C.
  26. 大韓韓醫學會誌 v.19 no.2 星香正氣散이 家의 頸動脈 平滑筋 緊張度 調節에 미치는 影響 金塋均;高祐新;金鍾勳
  27. Nature v.288 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine furchgott RF;Zawadzki JV
  28. Fed Proc. v.39 Acetylcholine relaxes arterial smooth muscle by releasing a relaxing substances from endothelial cells(abstr) Furchgott RF;Zawadzki JV
  29. Circ Res. v.64 Release of different relaxing factors by cultured porcine endothelial cells Boulanger C;Hendrickson H;Lorenz RR
  30. Nature v.323 Nitric oxide release accounts for the biological activity of endotheliumderived relaxing factor. Palmer RMJ;Ferrige AG;Moncada S.
  31. Br J Phamacol v.96 A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxtion Ress DD;Palmer RMJ;Hodson HF
  32. J Physiol. v.410 Some electrical properies of endothelium-derived hyperpolarization recorded from rat arterial smooth muscle cells Chen G;Suzuki H
  33. Br J Pharmacol. v.95 Acetylcholine relase endothelium derived hyperpolarizing factor and EDRF from rat blood vessels Chen G;Suzuki H;Weston AH
  34. Am J Physiol. v.259 Membrane hyperpolarization is a mechanism of endothelium-dependent cerebral vasodilation Brayden JE
  35. J Am Coll Cardiol. v.12 Endothelium-derived relaxing factor Griffith TM;Lewis MJ;Newby AC