Abstract
Purpose : This study is to find out the Ginseng Radix extract on rats nephrotoxicity when the rates were induced by Cs A. Methods : The experimental animals were divided into 3 groups and treated as follows: nothing was given to Sample A, Sample B was given normal saline after an I.V. injection of Cs A, and Sample C was given Ginseng Radix extract after a Cs A injection. The groups were observed for 14 days. After the prescription of the medicines, the following levels were tested: serum BUN, creatinine, total protein, sodium, potassium, and chloride ions. Results : 1. Changes in serum level. The levels of GPT, GOT, and BUN were significantly reduced in the experimental group when compared with those of the control group. The total protein level showed significant elevation when compared with those of the control group. The chloride level in the serum in the sample group was insignificantly reduced. The creatinine level was insignificantly increased. The Potassium level decreased, mildly. The Sodium and The Potassium levels in the serum in the sample group showed insignificantly lower levels than those of the control group. 2. Changes in the urine level. Urine specific gravity showed a significant increase, on the 14th day, in the experimental group when compared with that of the control group. The urinary ceatinine levels showed and insignificant increase, followed by an insignificant decrease. Conclusion : It can be inferred that Ginseng Radix may improve nephrotoxicity and hepatoxicity in rats when induced by Cyclosporin A.
