The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effects of Cordyceps Sinensis on Antioxidation in the Livers of Hydrocortisone Acetate-Treated Rats

동충하초(冬蟲夏草)가 hydrocortisone으로 유발시킨 양허(陽虛) 동물모형(動物模型)에서 항산화(抗酸化) 작용(作用)에 미치는 영향(影響)

  • Lee, Gu-Hyong (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Min, Gun-Woo (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Yoon, Cheol-Ho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Seo, Un-Kyo (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Han, Yeong-Hwan (Department of Biology, College of Natural Science, Dongguk Univ.) ;
  • Shin, Uk-Seob (Department of Pharmmacy, Dongguk Medical Center) ;
  • Park, Jong-Hyuck (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 이구형 (동국대학교 한의과대학 내과학교실) ;
  • 민건우 (동국대학교 한의과대학 내과학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 서운교 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 한영환 (동국대학교 자연과학대학 생물학과) ;
  • 신억섭 (동국대학교 의료원 약제과) ;
  • 박종혁 (동국대학교 한의과대학 내과학교실)
  • Published : 2001.03.30
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Abstract

Objectives : Cordyceps Sinensis (CS) was tested for the effects of antioxidant enzymes and lipid peroxidation in the liver. Methods : We measured the changes in body weight, enzyme activity, lipid peroxide and the death rate in the hydrocortisone acetate-treated rats. Results : In vitro, CS didn't effect levels of lipid peroxide. the activities, and the ratio of type conversion of xanthine oxidase. In the hydrocortisone acetate-treated rats, lipid peroxide, the activities, the ratio of type conversion of xanthine oxidase, and the death rate all increased. But, glutathione peroxidase and superoxide dismutase decreased. In vitro, after CS was administered to hydrocortisone acetatetreated rats, the levels of lipid peroxide in the liver, and the death rate decreased. However, the activities, and the ratio of type conversion of xanthine oxidase decreased. The body weight, glutathione peroxidase, and superoxide dismutase in+creased. The effects of Sinensis Cordyceps Broth did better than the effects of Sinensis Cordyceps Mycelia. Conclusions : These results suggest that CS decrease the activities of free radical generating enzymes which form lipid peroxide and increase the activities of oxygen free radical scavenging enzymes.

Keywords

References

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