대한한의학방제학회지 (Herbal Formula Science)

  • 제9권1호
  • /
  • Pages.273-288
  • /
  • 2001
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  • 1229-1218(pISSN)
  • /
  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

정천화담강기탕(定喘化痰降氣湯)이 ovalbumin으로 유발(誘發)된 천식(喘息)의 조직학적(組織學的) 변화(變化)에 미치는 영향(影響)

The Histologic Effects of Jungcheonhwadamgangki-tang Extract on the Experimental Asthma induced by ovalbumin

  • 이상준 (경산대학교 한의과대학 내과학교실) ;
  • 박지현 (경산대학교 한의과대학 내과학교실) ;
  • 최해윤 (경산대학교 한의과대학 내과학교실) ;
  • 김종대 (경산대학교 한의과대학 내과학교실)
  • Lee, Sang-Jun (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Park, Ji-Hyeon (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Choi, Hae-Yun (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Kim, Jong-Dae (Department of Internal Medicine, College of Oriental Medicine, Kyungsan University)
  • 발행 : 2001.12.20
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초록

Objectives : In order to study the effect of oral administration of Jungcheonhwadamgangki-tang against the asthma. Method : Asthma was induced to Balb/c mouse with ovalbumin by using method of Hatfield et al. It was observed the changes numbers and morphology of the mast cells in the trachea, numbers of mucous secretory cell in the bronchus, morphology of the bronchus, ultramicroscopical appearance of surface of trachea and number of cilia and mucous secretory cells by scanning electron microscope. Result : 1. Degranulation and decreasing of the numbers of mast cells were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. 2. Hypertrophy of mucous membrane of bronchus In the lung, infiltration of inflammatory cells, increasing of mucous secretory cells in the bronchus were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. 3. Shedding, decreasing of cilia cells and increasing of mucous secretory cells in the surface of the trachea were significantly decreased in the Jungcheonhwadamgangki-tang extract group as compared with control group. Conclusion : It is considered that Jungcheonhwadamgangki-tang has somewhat favorable effects on the asthma because the asthma specific series of abnormalities in respiratory system were decreased after oral administration of Jungcheonhwadamgangki-tang in this study. In future, it is needed that the toxicological and dosage specific study of Jungcheonwhadamgangki-tang to use against bronchial asthma with safe.

키워드

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