대한한의학방제학회지 (Herbal Formula Science)

  • 제9권1호
  • /
  • Pages.231-250
  • /
  • 2001
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  • 1229-1218(pISSN)
  • /
  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

인진호탕가웅담(茵蔯蒿湯加熊膽)의 경구투여(經口投與)가 $CCl_4$ 투여(投與)로 유발(誘發)된 간경변(肝硬變)에 미치는 영향(影響)

Effect of oral administration of Injinhotang with bile extract of bear on carbon tetrachloride $(CCl_4)-induced$ hepatic cirrhosis rat

  • 김건진 (경산대학교 한의과대학 방제학교실) ;
  • 이형식 (경산대학교 자연과학부) ;
  • 서부일 (경산대학교 한의과대학 제한동의 학술원) ;
  • 변성희 (경산대학교 한의과대학 제한동의 학술원) ;
  • 변준석 (경산대학교 한의과대학 제한동의 학술원) ;
  • 김상찬 (경산대학교 한의과대학 방제학교실)
  • Kim, Geon-Jin (College of Oriental Medicine, Kyungsan University) ;
  • Lee, Hyung-Sik (Faculty of Natural Science, Kyungsan University) ;
  • Seo, Bu-Il (Jeahan Oriental Medical Academy, Kyungsan University) ;
  • Byun, Sung-Hui (Jeahan Oriental Medical Academy, Kyungsan University) ;
  • Byun, Joon-Seok (Jeahan Oriental Medical Academy, Kyungsan University) ;
  • Kim, Sang-Chan (College of Oriental Medicine, Kyungsan University)
  • 발행 : 2001.12.20
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초록

In order to determine the effects of annexing bile extracts of bears on the anti-fibrotic effect of Injinhotang. Mix compound of Injinhotang and bile extracts of bears were administered to the carbon tetrachloride ($CCl_4$)-induced cirrhotic rats during 20 days and the changes of serum levels of GOT (glutamic-oxalacetic transaminase), GPT (glutamic pyruvic transaminase), LDH (lactate dehydrogenase), ALP (alanine phosphatase), GGT (gamma glutamyl transpeptidase) and T-BIL (total bilirubin) were monitored with comparison to the results of Injinhotang administered group. The results were summarized as follows. 1. A significant (p<0.01) increase of serum GOT levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. In addition, a significant (p<0.05) increase were also detected In Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 2. A significant (p<0.01) increase of serum GPT levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. Although significances were not recorded, increase of serum GPT levels were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 3. A significant (p<0.01) increase of serum LDH levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. Although significances were not recorded, increase of serum LDH levels were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 4. A significant (p<0.01 or p<0.05) increase of serum ALP levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. In addition, a significant (p<0.05) increase were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 5. A significant (p<0.01) increase of serum GGT levels were observed in control and Injinhotang-administered group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang with Fel Ursi-administered group. 6. A significant (p<0.01) increase of serum T-BIL levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. Although significances were not recorded, increase of serum T-BIL levels were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. In conclusion, it is considered that bile extract of bears has some additional effect to the anti-fibrotic effect of Injinhotang but to know the exact mechanism of suitable dose and duration of administration, further studies such as pharmacokinetics and dose-dependent pharmacological studies were needed

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