Journal of the Korean Association of Oral and Maxillofacial Surgeons
- Volume 27 Issue 5
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- Pages.373-384
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- 2001
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- 2234-7550(pISSN)
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- 2234-5930(eISSN)
STUDY ON MUTATION OF P53 AND EXPRESSION OF MDM-2 IN DMBA INDUCED CARCINOMA OF HAMSTER BUCCAL POUCH
DMBA로 유도된 햄스터 협낭암종에서 p53 유전자 변이와 mdm-2 단백의 발현에 관한 연구
- Park, Yong-Sun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
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Kim, Kyung-Wook
(Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
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Lee, Jae-Hoon
(Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
- Kim, Chang-Jin (Department of Pathology, College of Medicine, Soonchunhyang University)
- 박용선 (단국대학교 치과대학 구강악안면외과학교실) ;
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김경욱
(단국대학교 치과대학 구강악안면외과학교실) ;
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이재훈
(단국대학교 치과대학 구강악안면외과학교실) ;
- 김창진 (순천향대학교 의과대학 병리학교실)
- Published : 2001.10.30
Abstract
Cellular proliferation is an intricately regulated process mediated by the coordinated interactions of critical growth control genes. Two of these factors in mammalian cells are the p53 and mdm-2 genes. A protein product of the mem-2 oncogene has been recently shown to associate with the protein encoded by the tumor suppressor gene p53. The p53 tumor suppressor protein is stabilized in response to DNA damage and other stress signals and causes the cell to undergo growth arrest or apoptosis, thus preventing the establishment of mutations in future cellular generations. Mutation or loss of p53 is a very common event in tumor progression. It occurs in about 50% of all tumors analysed including of colon, lung, breast and liver. The cellular mdm-2 gene, which has potential transforming activity that can be activated by overexpression, is amplified in a significant percentage of human sarcoma and in other mammalian tumors. Proteins encoded by the mdm-2 gene are able to bind to the p53 protein and, when overexpressed, can inhibit p53's transcriptional activation function, thus mdm-2 can act as a negative regulator of p53 function. Experimental study was performed to observe the relationship between p53 gene mutation and mdm-2 protein expression and apply the results to the clinical activity. 36 golden syrian hamster each weighing
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