Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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IMMEDIATE LIVER FUNCTION AFTER ENFLURANE OR ISOFLURANE ANESTHESIA IN ORTHOGNATHIC SURGICAL PATIENTS.

악교정수술 환자에 있어서 Enflurane, isoflurane 흡입마취제가 간기능에 단기간 미치는 영향

  • Chang, Hyun-Ho (Oral & Maxillofacial Surgery, Dept. of Dentistry, Asan Medical Center, Medical College of Ulsan University) ;
  • Kim, Jae-Seung (Oral & Maxillofacial Surgery, Dept. of Dentistry, Asan Medical Center, Medical College of Ulsan University) ;
  • Kang, Jae-Hyun (Oral & Maxillofacial Surgery, Dept. of Dentistry, Asan Medical Center, Medical College of Ulsan University) ;
  • Lee, Seung-Ho (Oral & Maxillofacial Surgery, Dept. of Dentistry, Asan Medical Center, Medical College of Ulsan University)
  • 장현호 (울산대학교 의과대학 서울중앙병원 치과 구강악안면외과) ;
  • 김재승 (울산대학교 의과대학 서울중앙병원 치과 구강악안면외과) ;
  • 강재현 (울산대학교 의과대학 서울중앙병원 치과 구강악안면외과) ;
  • 이승호 (울산대학교 의과대학 서울중앙병원 치과 구강악안면외과)
  • Published : 2001.08.31
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Abstract

Isoflurane and enflurane are currently used on orthognathic surgery in Korea. Since starting to use enflurane and isoflurane in orthognathic surgery, we have questioned their effect on liver function. Many studies have reported liver function after enflurane and isoflurane anesthesia. Although both enflurane and isoflurane are less hepatotoxic than halothane, some cases of liver dysfunction have been reported after enflurane and isoflurane anesthesia. And, we know that isoflurane is less hepatotoxic than its predecessors, enflurane. But, fulminant liver failure and necrosis were also reported after isoflurane anesthesia. The purpose of this study was to compare immediate liver function in healthy orthognathic surgical patients receiving enflurane or isoflurane anesthesia. To assess the effect of enflurane and isoflurane on liver function, we measured pre-and post-operative serum concentrations of aspartate aminotransferase(AST), and alanine aminotransferase(ALT), alkaline phosphatase(ALP), total bilirubin(Tbil).

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