Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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THE EFFECT OF DECORIN, $TGF-{\beta}$ ANTAGONIST, ON WOUND HEALING IN RABBITS

가토에서 $TGF-{\beta}$ 길항제인 Decorin이 창상치유에 미치는 영향

  • Song, Sang-Hun (Dept. of Oral & Maxillofacial Surgery, Kangnam General Hospital, Public Corporation) ;
  • You, Jun-Young (Dept. of Oral & Maxillofacial Surgery, Kangnam General Hospital, Public Corporation) ;
  • Kim, Sun-Hun (Dept. of Oral Anatomy, College of Dentistry, Chonnam National University) ;
  • Kim, Min-Suk (Dept. of Oral Anatomy, College of Dentistry, Kangnung National University) ;
  • Yang, Byung-Eun (Dept. of Oral & Maxillofacial Surgery, Myongji Hospital, College of Medicine, Kwandong University)
  • 송상훈 (서울특별시 지방공사 강남병원 구강악안면외과) ;
  • 유준영 (서울특별시 지방공사 강남병원 구강악안면외과) ;
  • 김선헌 (전남대학교 치과대학 구강해부학교실) ;
  • 김민석 (강릉대학교 치과대학 구강해부학교실) ;
  • 양병은 (관동대학교 의과대학 명지병원 구강악안면외과)
  • Published : 2001.08.31
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Abstract

There have been many trials to decrease the scar formation followed by wound treatment. $TGF-{\beta}$ plays a important role on wound healing in adult. Therefore the repression of $TGF-{\beta}$ expression will be helpful to decrease scar formation. Decorin is known to competitively inhibit $TGF-{\beta}$ expression. Decorin were subcutaneously administered in surgical wounds in rabbits to investigate the preventing effect of scar formation for clinical application. Histologic findings of wound healing progresses is similar with control and experimental group at 2week. $2.5{\mu}g$ decorin of administrated group was similar to those of control group at 4 and 8week. In wound healing process $10{\mu}g$ decorin of administrated groupsat showed that thickness of immature collagen fibers(scar) was decreased as compared with control group at 4, 8 weeks. $20{\mu}g$ decorin of administrated group showed similar histologic features to $10{\mu}g$ administrated group. The wounds of 8week experimental group(10, $20{\mu}g$) were completely recovered to the normal surrounding skin tissue including sweat gland and hair follicle. These results suggested that decorin can be of help to the prevention of local scar formation.

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