Journal of Pharmaceutical Investigation
- 제31권3호
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- Pages.181-184
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- 2001
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Development of Transdermal Drug Delivery System for the Combination of Physostigmine and Procyclidine
- Park, Soon-Cheol (College of Pharmacy, Chosun University) ;
- Choi, Hoo-Kyun (College of Pharmacy, Chosun University)
- 발행 : 2001.09.20
초록
The purpose of this study was to develop transdermal drug delivery system (TDDS) for the combination of physostigmine and procyclidine. The effects of various pressure sensitive adhesives (PSA) on the percutaneous absorption of procyclidine across hairless mouse skin were evaluated to select an appropriate PSA. In addition, the influences of various vehicles on the percutaneous absorption of procyclidine from PSA matrix across hairless mouse skin were evaluated using flow-through diffusion cell system at