Journal of Pharmaceutical Investigation
- Volume 31 Issue 2
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- Pages.89-94
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- 2001
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Pharmacokinetics of Recombinant Human Granulocyte Colony Stimulating Factor (rhG-CSF) Following Intravenous, Intramuscular and Subcutaneous Administration of HM10411 and Filgrastim to Rats and Mice
인과립구 콜로니 자극인자 제제인 HM10411와 필그라스팀의 정맥, 근육 및 피하 주사시 흰쥐와 마우스에서의 약물 동태
-
Kim, In-Wha
(Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
- Lee, Sang-Hoon (Central Research Institute, Hanmi Pharm. Co. Ltd.) ;
- Kim, Young-Min (Central Research Institute, Hanmi Pharm. Co. Ltd.) ;
- Jung, Sung-Youb (Central Research Institute, Hanmi Pharm. Co. Ltd.) ;
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Kwon, Se-Chang
(Central Research Institute, Hanmi Pharm. Co. Ltd.) ;
- Lee, Gwan-Sun (Central Research Institute, Hanmi Pharm. Co. Ltd.) ;
- Chung, Suk-Jae (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
- Shim, Chang-Koo (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
-
김인화
(서울대학교 약학대학 종합약학 연구소) ;
- 이상훈 (한미약품공업주식회사) ;
- 김영민 (한미약품공업주식회사) ;
- 정성엽 (한미약품공업주식회사) ;
-
권세창
(한미약품공업주식회사) ;
- 이관순 (한미약품공업주식회사) ;
- 정석재 (서울대학교 약학대학 종합약학 연구소) ;
- 심창구 (서울대학교 약학대학 종합약학 연구소)
- Published : 2001.06.20
Abstract
The pharmacokinetics of recombinant human granulocyte colony stimulating factor (rhG-CSF) following intravenous (i.v.), intramuscular (i.m.) and subcutaneous (s.c.) administration of HM1041l-lyo and HM10411-liq (lyophilized and liquid formulations of rhG-CSF, recently under development by Hanmi Pharmaceutical Company) were studied in rats, and compared with that of Filgrastim (conventional formulation of rhG-CSF on market). The plasma concentration of rhG-CSF was quantified using a specific ELISA. The pharmacokinetic parameters of rhG-CSF, after i.v., i.m. and s.c. administration of Filgrastim, HM1041l-lyo and HM1041l-liq to rats at a rhG-CSF dose of
Keywords
- HM10411;
- Filgrastim;
- Recombinant human granulocyte colony stimulating factor (rhG-CSF);
- Pharmacokinetics;
- Administration routes;
- Dose-dependency;
- Species difference