Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지

Isolation of Eudesmanolides Derivatives from the Flower of Chrysanthemum coronarium L.

쑥갓 꽃에서 Eudesmanolide 유도체 분리

  • Lee, Kyung-Dong (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University) ;
  • Ha, Tae-Joung (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University) ;
  • Park, Ki-Hun (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University) ;
  • Yang, Min-Suk (Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University)
  • 이경동 (경상대학교 응용생명과학부) ;
  • 하태정 (경상대학교 응용생명과학부) ;
  • 박기훈 (경상대학교 응용생명과학부) ;
  • 양민석 (경상대학교 응용생명과학부)
  • Published : 2001.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Two sesquiterpene lactones were isolated from the flowers of Chrysanthemum coronarium L. by silica gel chromatography and recrystalization. Their structures were determined using various spectroscopic data, and were identified as eudesmanolide derivatives douglanine and reynosin, respectively. This is reported for the first time in this plant. The cytotoxic activity of two compounds showed strong activities against human cancer cell lines such as A549, PC-3 and HCT 116.

쑥갓(Chrysanthemum coronarium L.) 꽃으로부터 암 예방활성 성분을 가진 2종의 화합물을 분리하여 다양한 spectral data를 종합한 결과, sesquiterpene lactone계인 eudesmanolide의 일종으로 밝혀졌으며 , compound 1과 2는 각각 douglanine과 reynosin인 것으로 동정되었다. 이 화합물들은 쓱갓에서는 처음으로 분리 보고되는 화합물이며, 세포독성을 측정한 결과, 두 화합물 모두 3종의 인체암 세포주에 대하여 비교적 강한 활성을 나타내었다.

Keywords