한국식품과학회지 (Korean Journal of Food Science and Technology)
- 제33권5호
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- Pages.619-625
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- 2001
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- 0367-6293(pISSN)
90% 췌장 절제 백서에서 둥굴레뿌리의 물추출물이 인슐린 저항성에 미치는 영향
The Effects of Water Extract of Polygonatum Odoratum (Mill) Druce on Insulin Resistance in 90% Pancreatectomized Rats
- 박선민 (호서대학교 자연대학교 식품영양학과) ;
- 안승희 (호서대학교 자연대학교 식품영양학과) ;
- 최미경 (호서대학교 자연대학교 식품영양학과) ;
- 최수란 (호서대학교 자연대학교 식품영양학과) ;
- 최수봉 (건국대학교 의과대학 내과)
- Park, Sun-Min (Food and Nutrition, Hoseo University) ;
- Ahn, Seung-Hee (Food and Nutrition, Hoseo University) ;
- Choi, Mi-Kyung (Food and Nutrition, Hoseo University) ;
- Choi, Soo-Ran (Food and Nutrition, Hoseo University) ;
- Choi, Soo-Bong (Internal Medicine, KonKuk University)
- 발행 : 2001.10.01
초록
현재까지 인슐린의 작용력을 향상시키는 약으로 시판되고 있는 것은 thiazolidinediones이 있고 그외에도 몇가지 종류의 물질에 대해서 그 효과를 조사하고 있다. 본 연구에서는 당뇨병의 치료에 효과가 있다고 알려진 한약재로부터 추출한 POD의 인슐린 저항성에 미치는 영향을 조사하였다. 체중이
We determined whether the supplementation of Polygonatum Odoratum (Mill) Druce (POD) extract had a good effect on insulin resistance in peripheral tissues of 90% pancreatectomized (Px) and sham-operated (Sham) male Sprague Dawley rats. Px and Sham rats were divided into two groups; one group daily consumed 0.3 g of POD extracts per 1 ㎏ body weight for two months, and the other group had a placebo. All rats freely consumed a 40% fat diet. At the end of the experiment, a euglycemic hyperinsulinemic (EH) clamp was performed in a fasting, awake, and unstressed state to determine insulin resistance. At EH clamp, body weights were higher in Sham rats than Px rats, and serum glucose levels of baseline were affected by diabetic status and POD administration. Serum insulin concentrations were higher in Sham rats than Px rats, and POD administration decreased them in Sham rats compared to P. Glucose disposal rates in peripheral tissues increased with POD in both Px (n=10) and Sham (n=10) rats. But glycogen deposits in soleus muscle increased with POD administration in Px and Sham rats, and total glycogen synthase activity and fraction velocity were higher in POD groups. Triglyceride contents in quadriceps muscles decreased with POD in Px rats. In conclusions, POD improves insulin resistance by enhancing glucose utilization with increasing glycogen deposit and decreasing triglyceride contents in muscles.
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