Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibitory Effects of Medicinal Herbs on Diacylglycerol Acyltransferase Activity

Diacylglycerol Acyltransferase에 대한 생약자원의 저해활성 검색

  • Lee, Seung-Woong (Cadiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ko, Jung-Suk (Cadiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kwon, Oh-Eok (Cadiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Sang-Myung (Cadiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
  • Rho, Mun-Chual (Cadiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Kook (Cadiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyun-Sun (Cadiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology)
  • 이승웅 (한국생명공학연구원 순환기연구실) ;
  • 고정숙 (한국생명공학연구원 순환기연구실) ;
  • 권오억 (한국생명공학연구원 순환기연구실) ;
  • 이상명 (한국생명공학연구원 순환기연구실) ;
  • 김영호 (충남대학교 약학대학) ;
  • 노문철 (한국생명공학연구원 순환기연구실) ;
  • 김영국 (한국생명공학연구원 순환기연구실) ;
  • 이현선 (한국생명공학연구원 순환기연구실)
  • Published : 2001.09.30
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Abstract

The inhibitory effects of methanol extracts of 135 medicinal herbs on diacylglycerol acyltransferase (DGAT) activity were investigated. DGAT was partially purified from rat liver. Eleven kinds of methanol extracts of medicinal herbs including Evodiae Fructus showed a mild inhibitory effect with the concentration of $125\;{\mu}g/ml$ (above 40% inhibition). Six kinds of methanol extracts including Ephedrae Herba exhibited a weak inhibition. Among them, three kinds of butanol extracts (Sophorae Radix, Arecae Semen, Caesalpiniae Lignum) and the chloroform extracts of Evodiae Fructus showed significant inhibitory activities (above 60% inhibition) at the same concentration.

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