생약학회지 (Korean Journal of Pharmacognosy)

한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

수종 생약추출물의 muscarin성$(M_1\;type)$ acetylcholine 수용체$(mAChR-M_1)$에 대한 친화력 검색

Binding affinity of some herbal extracts on the muscarinic acetylcholine receptor subtype 1 $(mAChR-M_1)$

  • 김영섭 (한국화학연구원 화학물질연구부) ;
  • 김정섭 (한국화학연구원 화학물질연구부) ;
  • 김성기 (한국화학연구원 화학물질연구부) ;
  • 허정희 (한국화학연구원 화학물질연구부) ;
  • 이병의 (한국화학연구원 화학물질연구부) ;
  • 유시용 (한국화학연구원 화학물질연구부)
  • Kim, Young-Sup (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Kim, Jeoung-Seob (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Kim, Seong-Kie (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Heor, Jung-Hee (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Lee, Byung-Eui (Bio-Organic Science Division, Korea Research Institute of Chemical Technology) ;
  • Ryu, Shi-Yong (Bio-Organic Science Division, Korea Research Institute of Chemical Technology)
  • 발행 : 2001.09.30
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초록

The water extracts of 82 Korean medicinal herbs were examined for the binding affinity on the recombinant human muscarinic acetylcholine receptor subtype 1 $(mAChR-M_1)$ produced from the CHO (Chinese Hamster Ovary) cell line. Of those tested, the extracts of Coptidis Rhizoma, Phellodendri Cortex, Hedyotis Herba and of Terminariae Fructus were found to exhibit a significant competition with $[^3H]$ N-methyl-scopolamine for the specific binding to $mAChR-M_1$ in a dose dependent manner, respectively.

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