Korean Journal of Pharmacognosy (생약학회지)
- Volume 32 Issue 1 Serial No. 124
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- Pages.49-54
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- 2001
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Effects of Protoberberine Compounds on Serotonin Content in P815 Cells
Protoberberine 화합물이 P815 세포중의 serotonin 함량에 미치는 영향
- Lee, Myung-Koo (College of Pharmacy, Chungbuk National University) ;
- Kim, Eung-Il (College of Pharmacy, Chungbuk National University) ;
- Hur, Jae-Doo (Kwang Dong Pharmaceutical Co., Ltd.) ;
- Lee, Kyong-Soon (College of Pharmacy, Chungbuk National University) ;
- Ro, Jai-Seup (College of Pharmacy, Chungbuk National University)
- Published : 2001.03.30
Abstract
The effects of protoberberine compounds on serotonin biosynthesis in P815 cells were investigated. Protoberberine compounds such as berberine, palmatine and coralyne decreased serotonin content dose-dependently, but coptisine did not. The
Keywords
- protoberberine compounds;
- serotonin content;
- tryptophan hydroxylase;
- aromatic L-amino acid decarboxylase;
- P815 cells