The Korean Journal of Physiology and Pharmacology
- 제5권3호
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- Pages.213-221
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- 2001
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Dual Effect of Dynorphin A on Single-Unit Spike Potentials in Rat Trigeminal Nucleus
- Lee, Keun-Mi (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Han, Hee-Seok (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Jang, Jae-Hee (Department of Physiology, School of Medicine, Kyungpook National University) ;
- Ahn, Doug-Kuk (Department of Oral Physiology, School of Dentistry, Kyungpook National University) ;
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Park, Jae-Sik
(Department of Physiology, School of Medicine, Kyungpook National University)
- 발행 : 2001.06.21
초록
The amygdala is known as a site for inducing analgesia, but its action on the trigeminal nucleus has not been known well. Little information is available on the effect of dynorphin on NMDA receptor-mediated electrophysiological events in the trigeminal nucleus. The purpose of this study was to investigate the changes in the single neuron spikes at the trigeminal nucleus caused by the amygdala and the action of dynorphin on the trigeminal nucleus. In the present study, extracellular single unit recordings were made in the dorsal horn of the medulla (trigeminal nucleus caudalis) and the effects of microiontophoretically applied compounds were examined. When [D-Ala2, N-Me-Phe4, Glys5-ol]enkephalin (DAMGO, 10-25 mM), a