Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
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Effects of Sildenafil Citrate on Autonomic Nervous System in Normal Young Man

정상 젊은 성인 남성에서 Sildenafil Citrate가 자율신경계에 미치는 영향

  • Park, Moon-Ho (Department of Neurology, College of Medicine Korea University) ;
  • Koh, Seong-Beom (Department of Neurology, College of Medicine Korea University) ;
  • Kim, Byung-Jo (Department of Neurology, College of Medicine Korea University) ;
  • Park, Kun-Woo (Department of Neurology, College of Medicine Korea University) ;
  • Lee, Dae-Hie (Department of Neurology, College of Medicine Korea University)
  • 박문호 (고려대학교 의과대학 신경과학교실) ;
  • 고성범 (고려대학교 의과대학 신경과학교실) ;
  • 김병조 (고려대학교 의과대학 신경과학교실) ;
  • 박건우 (고려대학교 의과대학 신경과학교실) ;
  • 이대희 (고려대학교 의과대학 신경과학교실)
  • Published : 2001.12.30

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Abstract

Background: Sildenafil citrate$(Viagra^{\circledR})$ improves sexual functions in men with erectile dysfunction and is widely prescribed. But little is known about the effects of sildenafil citrate on autonomic nervous system. Methods : Seventeen health male subjects$(age\;26{\sim}36\;years)$ were investigated. Blood pressure (BP), heart rate(HR), and autonomic nervous function tests, such as BP rise in the sustained hand-grip, sympathetic skin reflex(SSR), HR variation with deep breathing(HR variation), and Valsalva ratio, were measured before and 60 minutes after administration of a single 50mg oral dose of sildenafil citrate. Results : Systolic BP were slightly decreased after sildenafil citrate administration $(118.8{\pm}11.77mmHg{\rightarrow}112.7{\pm}13.8mmHg,\;p=0.048)$. HR and diastolic BP were not changed significantly after sildenafil citrate administration. And autonomic nervous function tests were not changed significantly after sildenafil citrate. Conclusions : Sildenafil citrate does not cause significant changes in autonomic nervous system except systolic BP.

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