임상약리학회지 (Journal of Korean Society for Clinical Pharmacology and Therapeutics)
- 제9권1호
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- Pages.19-26
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- 2001
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- 1225-5467(pISSN)
레가론캅셀 $140^{\circledR}$ 및 국내 generic 제형의 약동학적 특성에 관한 비교 연구
Pharmacokinetic Comparison of Two Formulations Containing Silymarin : Legalon cap. $140^{\circledR}$ vs. a Generic Formulation
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임형석
(서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실,서울대학교병원 임상의학연구소 임상시험센터) ;
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이소영
(서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실,서울대학교병원 임상의학연구소 임상시험센터) ;
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조주연
(서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실,서울대학교병원 임상의학연구소 임상시험센터) ;
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배균섭
(서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실,서울대학교병원 임상의학연구소 임상시험센터) ;
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유경상
(서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실,서울대학교병원 임상의학연구소 임상시험센터) ;
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임동석
(가천의대 가천길병원 약리학과) ;
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장인진
(서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실,서울대학교병원 임상의학연구소 임상시험센터) ;
- 신상구 (서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실,서울대학교병원 임상의학연구소 임상시험센터)
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Lim, Hyeong-Seok
(Department of Pharmacology, Seoul National University College of Medicine, Clinical Pharmacology Unit and Clinical Trial Center, Seoul National University Hospital) ;
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Yi, So-Young
(Department of Pharmacology, Seoul National University College of Medicine, Clinical Pharmacology Unit and Clinical Trial Center, Seoul National University Hospital) ;
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Cho, Joo-Youn
(Department of Pharmacology, Seoul National University College of Medicine, Clinical Pharmacology Unit and Clinical Trial Center, Seoul National University Hospital) ;
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Bae, Kyun-Seop
(Department of Pharmacology, Seoul National University College of Medicine, Clinical Pharmacology Unit and Clinical Trial Center, Seoul National University Hospital) ;
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Yu, Kyung-Sang
(Department of Pharmacology, Seoul National University College of Medicine, Clinical Pharmacology Unit and Clinical Trial Center, Seoul National University Hospital) ;
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Yim, Dong-Seok
(Department of Pharmacology, Gachon Medical School) ;
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Jang, In-Jin
(Department of Pharmacology, Seoul National University College of Medicine, Clinical Pharmacology Unit and Clinical Trial Center, Seoul National University Hospital) ;
- Shin, Sang-Goo (Department of Pharmacology, Seoul National University College of Medicine, Clinical Pharmacology Unit and Clinical Trial Center, Seoul National University Hospital)
- 발행 : 2001.06.30
초록
Background : Silymarin formulations show low bioavailability due to its poor solubility. Therefore, developing a formulation which could improve bioavailability was a major issue. In Korea, there are many kinds of silymarin-containing formulations, including Legalon cap.