BMB Reports
- 제33권6호
- /
- Pages.525-530
- /
- 2000
- /
- 1976-670X(eISSN)
Involvement of Cytosolic Phospholipase $A_2$ in Nerve Growth Factor-Mediated Neurite Outgrowth of PC12 Cells
- Choi, Soon-Wook (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
- Yu, Eun-Ah (Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
- Lee, Young-Seek (Department of Biochemistry, College of Science, Hanyang University) ;
-
Yoo, Young-Sook
(Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology)
- 투고 : 2000.10.10
- 심사 : 2000.11.14
- 발행 : 2000.11.30
초록
The nerve growth factor (NGF) induces neuronal differentiation and neurite outgrowth of PC12 cells, whereas epidermal growth factors (EGF) stimulate growth and proliferation of the cells. In spite of this difference, NGF-or EGF-treated PC12 cells share various properties in cellular-signaling pathways. These include the activation of the phosphoinositide (PI)-3 kinase, 70 kDa S6 kinase, and in the mitogen-activated protein (MAP) kinase pathway, following the binding of these growth factors to intrinsic receptor tyrosine kinases (RTKs). Therefore, many studies have been attempted to access the critical signaling events in determining the differentiation and proliferation of PC12 cells. In this study, we investigated the cytosolic phospholipase