BMB Reports
- Volume 33 Issue 5
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- Pages.402-406
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- 2000
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- 1976-670X(eISSN)
Expression of ${\alpha}_1$ -Acid Glycoprotein and Inflammatory Cytokines during Differentiation of HL-60 Cells
- Lee, Il-Ha (Chemistry Section, Department of Natural Sciences, College of Medicine, The Catholic University of Korea) ;
- Kim, In-Sook (Chemistry Section, Department of Natural Sciences, College of Medicine, The Catholic University of Korea) ;
- Lee, Soo-Young (Chemistry Section, Department of Natural Sciences, College of Medicine, The Catholic University of Korea)
- Received : 2000.08.07
- Accepted : 2000.09.04
- Published : 2000.09.30
Abstract
In order to understand the role of AGP on the differentiation of promyelocytic leukemia cells, the AGP expression and its relation to cytokines were investigated during granulocytic or monocytic differentiation of HL-60 cells. When HL-60 cells were treated with all-trans-retinoic acid (ATRA) for 5 days, the cells were fully differentiated into granulocytes, and the AGP mRNA and protein levels were continuously increased up to 5 days in a dose- and time- dependent manner. However, in the case of the monocytic differentiation of HL-60 cells by tetradeanoyl phorbol acetate (TPA), the AGP gene expression was not induced. In addition,
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