BMB Reports
- Volume 33 Issue 1
- /
- Pages.1-36
- /
- 2000
- /
- 1976-670X(eISSN)
Acetohydroxyacid Synthase
- Duggleby, Ronald G. (Centre for Protein Structure, Function and Engineering, Department of Biochemistry, University of Queensland) ;
- Pang, Siew Siew (Centre for Protein Structure, Function and Engineering, Department of Biochemistry, University of Queensland)
- Received : 1999.12.10
- Published : 2000.01.31
Abstract
Acetohydroxyacid synthase (EC 4.1.3.18) catalyses the first reaction in the pathway for synthesis of the branched-chain amino acids. The enzyme is inhibited by several commercial herbicides and has been subjected to detailed study over the last 20 to 30 years. Here we review the progress that has been made in understanding its structure, regulation, mechanism, and inhibition.
Keywords
- acetohydroxyacid synthase;
- branched-chain aminoacids;
- enzyme regulation;
- FAD;
- herbicide inhibition;
- herbicide resistance;
- thiamin diphosphate;
- subunits