Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Carbamazepine Induced Bronchiolitis Obliterans Organizing Pneumonia

Carbamazepine으로 유발된 Bronchiolitis Obliterans Organizing Pneumonia 1예

  • Ok, Kyung-Seon (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Park, Bong-Keon (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Kim, Hee-Suk (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Lee, Hye-Kyung (Department of Pathology, College of Medicine, Inje University) ;
  • Jin, Seong-Lim (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Chin, Jae-Yong (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Lee, Hyuk-Pyo (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Kim, Joo-In (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Choi, Soo-Jeon (Department of Internal Medicine, College of Medicine, Inje University) ;
  • Yum, Ho-Kee (Department of Internal Medicine, College of Medicine, Inje University)
  • 옥경선 (인제대학교 의과대학 내과학교실) ;
  • 박봉건 (인제대학교 의과대학 내과학교실) ;
  • 김희숙 (인제대학교 의과대학 내과학교실) ;
  • 이혜경 (인제대학교 의과대학 병리학교실) ;
  • 진성림 (인제대학교 의과대학 내과학교실) ;
  • 진재용 (인제대학교 의과대학 내과학교실) ;
  • 이혁표 (인제대학교 의과대학 내과학교실) ;
  • 김주인 (인제대학교 의과대학 내과학교실) ;
  • 최수전 (인제대학교 의과대학 내과학교실) ;
  • 염호기 (인제대학교 의과대학 내과학교실)
  • Published : 2000.05.30
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Abstract

BOOP(Bronchiolitis Obliterans Organizing Pneumonia) is an inflammatory reaction that follows damage to the bronchiolar epithelium of the small conducting airways. BOOP is characterized by the pathologic finding of excessive proliferation of granulation tissue within the respiratory bronchioles, alveolar duct and spaces, accompanied by organizing pneumonia in the more distal parenchyma BOOP may result from diverse causes such as toxic fumes, connective tissue disorders, infections, organ transplantation and drugs or appear idiopathically. Drug induced BOOP has been described in association with acebutolol, amiodarone, cephalosporin, bleomycine, tryptophan, gold salts, barbiturates, sulfasalazine, and carbamazepine. Carbamazepine is an iminostilbene derivative that is used as both an anticonvulsant and pain reliever for pains associated with trigeminal neuralgia. It is structually related to the tricyclic antidepressants. To our knowledge, there have been no previously reported case that has described development of BOOP during carbamazepine treatment in Korea, and only two cases have been reported in the world. We report a case carbamazepine-induced BOOP with a brief review of literature.

약제 유발성 BOOP의 경우는 약을 중단하여도 증상과 방사선학적 소견이 호전되지 않을 수 있고 부신피질스테로이드를 사용한 후 뚜렷한 호전을 보일 수 있기 때문에 BOOP를 일으킬 수 있는 약제에 대한 인지가 진단과 치료에 중요하다. 저자들은 carbamazepine에 의한 BOOP 1예를 경험하였기에 보고하는 바이다.

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