The Korean Journal of Pain
- Volume 13 Issue 2
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- Pages.143-148
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- 2000
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Fos Protein Expression in Trigeminal Nociceptive Central Pathway of the Rat Brain by Cisternal Capsaicin Injection
흰쥐에서 Capsaicin 대조(Cisterna Magna) 내 주입 후 삼차신경 유해자극수용전달로에서의 Fos 단백의 발현
- Chung, Sung-Woo (Department of Neurology, College of Medicine, The Catholic University of Korea) ;
- Kim, Yeong-In (Department of Neurology, College of Medicine, The Catholic University of Korea) ;
- Kim, Sung-Nyeun (Department of Anesthesiology, College of Medicine, The Catholic University of Korea)
- Published : 2000.11.30
Abstract
Background: Trigeminovascular system is implicated in the pathophysiology of the headache in migraine. This study was designed to evaluate the pattern of Fos protein expression in trigeminal nociceptive central pathway after meningeal stimulation of rats by capsaicin. Methods: The expression of Fos protein was examined by immunohistochemistry in thalamus, brainstem and upper cervical cord (at three levels corresponding to obex, 0.8 mm and 2 mm below obex) 2 hours after intracisternal injection of either diluted capsaicin solution (0.1 ml,