The Korean Journal of Pain
- 제13권2호
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- Pages.137-142
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- 2000
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
백서를 이용한 포르말린 통증 모형하에서 뇌실 내 Gabapentin의 효과
The Effect of Intracerebroventricular Gabapentin on the Formalin Test in Rats
- 윤명하 (전남대학교 의과대학 마취통증의학교실) ;
- 곽상현 (전남대학교 의과대학 마취통증의학교실) ;
- 정성수 (전남대학교 의과대학 치과대학) ;
- 유경연 (전남대학교 의과대학 마취통증의학교실) ;
- 정창영 (전남대학교 의과대학 마취통증의학교실) ;
- 임웅모 (전남대학교 의과대학 마취통증의학교실)
- Yoon, Myung-Ha (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
- Kwak, Sang-Hyun (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
- Chung, Sung-Su (Department of College of Dentistry, Chonnam National University, Medical School) ;
- Yoo, Kyung-Yeon (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
- Jeong, Chang-Young (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
- Im, Woong-Mo (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School)
- 발행 : 2000.11.30
초록
Background: Systemic or intrathecal administration of gabapentin has been shown to reverse various pain states. However, until now, the effect of intracerebroventricular (ICV) gabapentin to noxious stimuli has not been reported. The authors' aim of this study was to determine the effect of ICV gabapentin on the inflammatory nociceptive model, formalin test, in rats. Methods: ICV catheters were implanted under halothane anesthesia. For the nociceptive test,
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