The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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The Effect of Intracerebroventricular Gabapentin on the Formalin Test in Rats

백서를 이용한 포르말린 통증 모형하에서 뇌실 내 Gabapentin의 효과

  • Yoon, Myung-Ha (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
  • Kwak, Sang-Hyun (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
  • Chung, Sung-Su (Department of College of Dentistry, Chonnam National University, Medical School) ;
  • Yoo, Kyung-Yeon (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
  • Jeong, Chang-Young (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School) ;
  • Im, Woong-Mo (Department of Anesthesiology, Pain Medicine, Chonnam National University, Medical School)
  • 윤명하 (전남대학교 의과대학 마취통증의학교실) ;
  • 곽상현 (전남대학교 의과대학 마취통증의학교실) ;
  • 정성수 (전남대학교 의과대학 치과대학) ;
  • 유경연 (전남대학교 의과대학 마취통증의학교실) ;
  • 정창영 (전남대학교 의과대학 마취통증의학교실) ;
  • 임웅모 (전남대학교 의과대학 마취통증의학교실)
  • Published : 2000.11.30
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Abstract

Background: Systemic or intrathecal administration of gabapentin has been shown to reverse various pain states. However, until now, the effect of intracerebroventricular (ICV) gabapentin to noxious stimuli has not been reported. The authors' aim of this study was to determine the effect of ICV gabapentin on the inflammatory nociceptive model, formalin test, in rats. Methods: ICV catheters were implanted under halothane anesthesia. For the nociceptive test, $50{\mu}l$ of 5% formalin was subcutaneously injected into the hindpaw. The effect of ICV gabapentin, administered 10 min before formalin injection, were examined on flinching, mean arterial pressure and heart rate evoked by a injection of formalin. Results: Injection of formalin into the paw resulted in a biphasic flinching and cardiovascular response. ICV gabapentin produced a dose-dependent suppression of the flinching and mean arterial pressure response during phase 1. In contrast, in phase 2, ICV gabapentin did not attenuate the pain behavior. ICV gabapentin did not affect on the baseline mean arterial pressure and heart rate. Conclusions: ICV gbapentin was effective for the acute noxious stimulus but it had no effect on the facilitated states induced by tissue injury.

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