대한두경부종양학회지 (Korean Journal of Head & Neck Oncology)
- 제16권1호
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- Pages.3-8
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- 2000
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- 1229-5183(pISSN)
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- 2586-2553(eISSN)
두경부 선양낭성암종에서 형광동소결합을 이용한 제17번 염색체의 다염색체 소견
Fluorescence In Situ Hybridization Analysis for Polysomy of Chromosome 17 in Head and Neck Adenoid Cystic Carcinomas
- 최건 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
- 박재형 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
- 최충식 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
- 송재준 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
- 정광윤 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
- 최종욱 (고려대학교 의과대학 이비인후-두경부외과학교실)
- Choi Geon (Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
- Park Jae-Hyung (Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
- Choi Choong-Sik (Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
- Song Jae-Joon (Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
- Jung Kwang-Yoon (Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
- Choi Jong-Ouck (Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine)
- 발행 : 2000.05.01
초록
Background and Objectives: Adenoid cystic carcinoma of salivary glands is characterized by insidious growth over many years, local recurrences, and distant metastasis and classified to three distinct histologic subtypes: tubular, cribriform, and solid. The solid type is known to have the worst prognosis. However, histopathologic heterogeneity is observed in tumors from the same patient. We have attempted to elucidate the genotypic differences, characterized by polysomies of chromosome 17, in adenoid cystic carcinoma according to the phenotypic histopathologic heterogeneity. Materials and Methods: Fluorescence in situ hybridization was performed on formalin-fixed paraffin blocks from seven patients with head and neck adenoid cystic carcinoma, using the centromeric