Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Progressive Multifocal Leukoencephalopathy in a Patient with T Cell Lymphoma of Head and Neck - A Case Report -

두경부 T 세포 림프종 환자에서 발생한 진행성 다초점성 백질뇌병증 - 증 례 보 고 -

  • Shin, Dong Ah (Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine) ;
  • Chang, Jong Hee (Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine) ;
  • Chang, Jin Woo (Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine) ;
  • Park, Yong Gou (Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine) ;
  • Kim, Tai Seung (Department of Pathology, Yonsei University College of Medicine) ;
  • Chung, Sang Sup (Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine)
  • 신동아 (연세대학교 의과대학 신경외과학교실, 뇌연구소) ;
  • 장종희 (연세대학교 의과대학 신경외과학교실, 뇌연구소) ;
  • 장진우 (연세대학교 의과대학 신경외과학교실, 뇌연구소) ;
  • 박용구 (연세대학교 의과대학 신경외과학교실, 뇌연구소) ;
  • 김태승 (연세대학교 의과대학 병리학교실) ;
  • 정상섭 (연세대학교 의과대학 신경외과학교실, 뇌연구소)
  • Received : 2000.07.26
  • Accepted : 2000.08.17
  • Published : 2000.12.28
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Abstract

Progressive multifocal leukoencephalopathy(PML) is a fatal demyelinating disease that occurs in immunocompromised hosts. We report a case of PML that developed in patient with T cell lymphoma of head and neck. During chemotherapy for lymphoma, she was confused and had memory impairment. A magnetic resonance imaging of the brain revealed confluent signal change at white matter of the frontal lobe, insula, and anterior limb and genu of internal capsule. The lesion was confirmed with brain biopsy and the histopathological finding was compatible with PML.

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