Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Lymphocytic Infundibuloneurohypophysitis : Case Report and Review of the Literature

림프구성 누두신경뇌하수체염 : 증례 보고 및 문헌고찰

  • Son, Young-Je (Department of Neurosurgery, Seoul National University College of Medicine, Neuroscience Research Institute, Seoul National University Medical Research Center) ;
  • Wang, Kyu-Chang (Department of Neurosurgery, Seoul National University College of Medicine, Neuroscience Research Institute, Seoul National University Medical Research Center) ;
  • Choe, Gheeyoung (Department of Pathology, Seoul National University College of Medicine, Neuroscience Research Institute, Seoul National University Medical Research Center) ;
  • Chi, Je Keun (Department of Pathology, Seoul National University College of Medicine, Neuroscience Research Institute, Seoul National University Medical Research Center) ;
  • Cho, Byung-Kyu (Department of Neurosurgery, Seoul National University College of Medicine, Neuroscience Research Institute, Seoul National University Medical Research Center)
  • 손영제 (서울대학교 의과대학 신경외과학교실, 서울대학교 의학연구원 신경과학연구소) ;
  • 왕규창 (서울대학교 의과대학 신경외과학교실, 서울대학교 의학연구원 신경과학연구소) ;
  • 최기영 (서울대학교 의과대학 병리학교실, 서울대학교 의학연구원 신경과학연구소) ;
  • 지제근 (서울대학교 의과대학 병리학교실, 서울대학교 의학연구원 신경과학연구소) ;
  • 조병규 (서울대학교 의과대학 신경외과학교실, 서울대학교 의학연구원 신경과학연구소)
  • Received : 1999.09.16
  • Accepted : 1999.12.10
  • Published : 2000.06.28
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Abstract

Lymphocytic infundibuloneurohypophysitis is a rare inflammatory disorder, which may be caused by autoimmune response, affecting the infundibulum and the posterior lobe of the pituitary gland. The authors present a 15-year-old man with central diabetes insipidus, whose sellar magnetic resonance imaging (MRI) showed a focal thickening of the infundibulum and loss of high signal of the normal neurohypophysis on T1-weighted images. The histopathological diagnosis was lymphocytic infundibuloneurohypophysitis. When a patient presents with central diabetes insipidus and infundibular thickening on brain MRI, this entity should be included in the differential diagnosis though it is very rare. The significance of this entity in treatment is that it is basically not a surgical one, and surgery is needed only for tissue diagnosis. Symptomatic treatment and observation make it regress spontaneously.

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