Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Apoptosis and Bcl-2 in Astrocytic Tumors

성상교세포종에서 Apoptosis와 Bcl-2 발현

  • Jang, Yeon Gyoe (Department of Neurosurgery, Wonju College of Medicine, Yonsei University) ;
  • Whang, Kum (Department of Neurosurgery, Wonju College of Medicine, Yonsei University) ;
  • Hong, Soon-Won (Department of Pathology, Wonju College of Medicine, Yonsei University)
  • 장연규 (연세대학교 원주의과대학 신경외과학교실) ;
  • 황금 (연세대학교 원주의과대학 신경외과학교실) ;
  • 홍순원 (연세대학교 원주의과대학 해부병리학교실)
  • Received : 1999.11.15
  • Accepted : 2000.01.14
  • Published : 2000.04.28
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Abstract

Objective : To study the expression of apoptosis and bcl-2 in the astrocytic tumors. Patients and Methods : A total of thirty-eight astrocytomas(9 cases in low grade astrocytoma, 12 cases in anaplastic astrocytoma and 17 cases in glioblastoma) are included in this study. Immunohistochemical stain for bcl-2 using monoclonal antibody, in situ end labelling technique for apoptosis were used. Results : The malignant group(anaplastic astrocytoma and glioblastoma) showed significantly higher apoptosis positive index(PI) compared to the benign group(low grade astrocytoma)(1.35 vs 0.14). However apoptosis PI and bcl-2 PI were not significantly different among three groups. Correlation between apoptosis PI and bcl-2 PI was not statistically significant(p=0.58). Conclusion : This result suggest that apoptosis PI and bcl-2 PI are not related the degree of malignancy in astrocytic neoplasm, but apoptosis PI in malignant group was higher possibly due to greater DNA damage.

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