Journal of Korean Neurosurgical Society
- 제29권1호
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- Pages.28-34
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- 2000
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- 2005-3711(pISSN)
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- 1598-7876(eISSN)
Lipoxygenase 및 Cyclooxygenase Inhibitor가 뇌수막종세포의 성장에 미치는 영향
The Effects of Lipoxygenase and Cyclooxygenase Inhibitors to Meningioma Cell Proliferation in vitro
- 박용석 (동국대학교 의과대학 신경외과학교실) ;
- 구태헌 (동국대학교 의과대학 신경외과학교실) ;
- 이정훈 (클리브랜드 클리닉 신경외과) ;
- 이영배 (동국대학교 의과대학 신경외과학교실) ;
- 이규춘 (동국대학교 의과대학 신경외과학교실) ;
- 목진호 (동국대학교 의과대학 신경외과학교실) ;
- 김한식 (동국대학교 의과대학 신경외과학교실)
- Park, Yong Seok (Department of Neurosurgery, Dongguk University Hospital) ;
- Koo, Tae Heon (Department of Neurosurgery, Dongguk University Hospital) ;
- Lee, Jung Hoon (Department of Neurosurgery, Cleveland Clinic) ;
- Lee, Young Bae (Department of Neurosurgery, Dongguk University Hospital) ;
- Lee, Kyu Chun (Department of Neurosurgery, Dongguk University Hospital) ;
- Mok, Jin Ho (Department of Neurosurgery, Dongguk University Hospital) ;
- Kim, Han Sik (Department of Neurosurgery, Dongguk University Hospital)
- 투고 : 1999.04.21
- 심사 : 1999.06.23
- 발행 : 2000.01.28
초록
Object : To verify the effect of the lipoxygenase inhibitor and cycloxygenase inhibitor on meningioma cell proliferation. Method : Using two meningioma cell lines, cell proliferation was determined at 96 hrs after adding inhibitor (AA861, Nordihydroguaiaretic acid(NDGA), Indomethacin, acetyl-11-keto-beta-boswellic acid(AKBA) into medium by methyl tetrazolium salt/phenazine methosulfate(MTS/PMS) non-radioactive cell proliferation assay. We checked optical density with 490nm wavelength UV and this value was used as a proliferative index. The percent of inhibition was also calculated from this value. Conclusion : Indomethacin and NDGA showed no effect on meningioma proliferation. AA861 also showed no significant inhibitory effect, but AKBA demonstrated a significant inhibitory effect on meningioma cell proliferation.