Journal of Haehwa Medicine (혜화의학회지)
- Volume 9 Issue 1
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- Pages.169-182
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- 2000
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- 2586-3002(pISSN)
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- 2586-3347(eISSN)
Study on Antitumor Activity of Bujeongyangeumtang(BJYET)
부정양음양(扶正養陰陽)의 항암활성(抗癌活性)에 관(關)한 연구(硏究)(I)
- Song, Min-Ho (Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University) ;
- Choe, Bong-Gyun ;
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Kim, Dong-Hee
(Dept. of Oriental Medicine Pathology, College of Oriental Medicine, Taejon University)
- Published : 2000.08.25
Abstract
To evaluate the antitumor activity and antimetastatic effects of Bujeongyangeumtang(BJYET), studies were done experimentally. The results were obtained as follows: 1. BJYET extracts exhibited a significant cytotoxicity against A549, SK-MEL-2, SK-OV-3 and B16-BL6 cell lines. 2. The T/C% was 118.2% in BJYET treated group in S-180 bearing ICR mice. 3. BJYET extracts exhibited inefficient adhesive effect of A549, B16-BL6 cell to complex extracellular matrix. 4. BJYET extracts showed a significant inhibition of lung metastasis of B16-BL6 cells in C57BL/6. 5. In vitro neovascularization assays, angiogenesis was significantly inhibited in BJYET treated group than control group. These results suggested that BJYET extracts might be usefully applied for prevention and treatment of cancer.
Keywords